Data on more than 12.6 million people over 51 years: An analysis of the risk of colorectal cancer from diabetes is expected to rewrite the guidelines

Recently, the International Agency for Research on Cancer (IARC), part of the World Health Organization, released the latest global cancer burden report for 2020.
report provides a comprehensive analysis of the types of cancers that are common around the world by 2020, the types of major cancers that cause death, and future cancer trends.
, there will be 19.3 million new types of cancer and nearly 10 million deaths in 2020, according to new cancer data.
report, we can see that colorectal cancer (CRC) is the third most common cancer in the world, and the second leading cause of cancer death, and the world's leading cause of morbidity and death in the digestive system malignancies.
last August, Hollywood actor Chadwick Bosman, who starred in the Avengers movie series "Black Panther," died of colon cancer at his home in Los Angeles, leading to a wave of colonoscopy screenings.
CRC is a preventable cancer.
undeniably, screening methods, including colonoscopy, have been effective in older populations since CRC screening becoming widespread.
based on a U.S. study, showed a decrease in the incidence of CRC after the introduction of intestinal screening.
, the incidence of CRC is increasing among young and middle-aged people who have not reached screening age.
many researchers say screening guidelines should be adjusted.
, diabetes and CRC share a common risk factor, both of which are younger, but the risk of CRC in diabetics is still unknown.
, the study, led by the German Cancer Research Centre, provides a comprehensive study of the risk of CRC in diabetics.
researchers used Sweden's national registration data for a total of 51 years from 1964 to 2015.
included 12614,256 first-time residents aged 0-107 with genealogy information.
follow-up period, a total of 162,226 people developed CRC and 559,375 had diabetes, of whom 18 per cent (101,135) were diagnosed with diabetes under the age of 50.
further analysis found that with the most common first screening age (50 years) as the threshold, the cumulative risk of 10-year CRC for men and women aged 50 was 0.44% and 0.41%, respectively.
, diabetics reached CRC screening levels earlier than the general population.
, men with diabetes (diagnosed before the age of 50) had a 0.44 per cent CRC risk at age 45 (five years earlier than the recommended age), compared with four years earlier for women.
addition, for people with an additional CRC family history, the increased risk was more pronounced when corrected according to gender and baseline screening age.
relationship between the cumulative risk of CRC in men and women and diabetes and age.
then, looking at the 45-year-old male and female sex found a cumulative risk of 0.25 per cent of the 10-year CRC.
same time, men with diabetes (diagnosed before the age of 45) are at 40 years of age and have reached the CRC risk of 45-year-old men in the general population (five years earlier than the recommended age), compared with three years earlier for women.
addition, it is even more surprising that patients with a history of diabetes and a family history of CRC are 14 years (31 years) ahead of the general population at age 45! Different benchmarks determine the age at which CRC will be screened for the first time.
, the study suggests that people with diabetes should bring their colorectal cancer screening age forward appropriately, and for people with an additional family history of bowel cancer, more attention should be paid to early individual screening.
: Ali Khan U, Fallah M, Sundquist K, et al. Risk of colorectal cancer in patients with diabetes mellitus: A Swedish nationwide cohort study. PLoS Med. 2020 Nov 13; 17(11):e1003431. doi: 10.1371/journal.pmed.1003431.MedSci Original Source: MedSci Original Copyright Notice: All text, images and audio and video materials on this website that indicate "Source: Met Medical" or "Source: MedSci Original" are owned by Mets Medical and are not authorized to reproduce, and any media, website or individual may not be reproduced under the copyright.
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