echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Medical News > Medical Research Articles > DCPA A60-Dry granulation and a better choice for water-sensitive API

    DCPA A60-Dry granulation and a better choice for water-sensitive API

    • Last Update: 2021-07-31
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

    DI-CAFOS ® A60 has a unique spherical particle morphology.


    Performance

    Table 1.




    A60 electron micrograph:





    Good partner for water sensitive API



    □ More and more APIs are sensitive to water and will degrade when in contact with water


    □ A60 is an anhydrous material with low specific surface area and very small porosity, and has very low hygroscopicity, so it is a good partner for water-sensitive APIs






    □ More and more APIs are sensitive to water and will degrade when in contact with water
    .

    □ A60 is an anhydrous material with low specific surface area and very small porosity, and has very low hygroscopicity, so it is a good partner for water-sensitive APIs
    .


    Figure 2.
    Comparison of dynamic vapor adsorption between A60 and A12

    → Conclusion: Comparing different models of anhydrous calcium hydrogen phosphate, A60 has much lower hygroscopicity than A12.


    A60 and dry granulation


    □ Dry granulation is an advanced technology
    .

    □ Compared with wet granulation, dry granulation has obvious advantages: shorten working hours, reduce equipment, reduce operation steps, eliminate the influence of moisture or drying on API, and dry press granulation can obtain high-density granules
    .


    Figure 3.
    Diagram of dry granulation

    □ A60 is a very suitable material for dry granulation.
    It can produce denser granules and has excellent reprocessing performance
    .
    This point of view will be verified by two experiments below .



    Figure 4 Two types of compaction strength and the density of compacted particles under different models of anhydrous calcium hydrogen phosphate


    →  It can be seen from Figure 4 that in different models of anhydrous calcium hydrogen phosphate, under the same compaction strength, A60 can produce denser particles
    .



    Figure 5.
    Recompressibility of anhydrous calcium hydrogen phosphate compacted granules


    →   Calculate the recompressibility (or reprocessing potential) of the particles from the area under the compression curve
    .

    →  It can be seen from Figure 5 that among the different models of anhydrous calcium hydrogen phosphate, A60 has relatively better reprocessing potential
    .

    Customers of direct compression and dry granulation processes are welcome to apply for free samples .
    We will contact you as soon as possible to recommend and mail samples for you
    .

    Company Name: Shenzhen Youpuhui Pharmaceutical Co.
    , Ltd.

    Contact number: 18126405453


    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.