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DI-CAFOS ® A60 has a unique spherical particle morphology.
Performance
Table 1.
A60 electron micrograph:
Good partner for water sensitive API
□ More and more APIs are sensitive to water and will degrade when in contact with water
□ A60 is an anhydrous material with low specific surface area and very small porosity, and has very low hygroscopicity, so it is a good partner for water-sensitive APIs
□ More and more APIs are sensitive to water and will degrade when in contact with water
.
□ A60 is an anhydrous material with low specific surface area and very small porosity, and has very low hygroscopicity, so it is a good partner for water-sensitive APIs
.
Figure 2.
Comparison of dynamic vapor adsorption between A60 and A12
→ Conclusion: Comparing different models of anhydrous calcium hydrogen phosphate, A60 has much lower hygroscopicity than A12.
A60 and dry granulation
□ Dry granulation is an advanced technology
.
□ Compared with wet granulation, dry granulation has obvious advantages: shorten working hours, reduce equipment, reduce operation steps, eliminate the influence of moisture or drying on API, and dry press granulation can obtain high-density granules
.
Figure 3.
Diagram of dry granulation
□ A60 is a very suitable material for dry granulation.
It can produce denser granules and has excellent reprocessing performance
.
This point of view will be verified by two experiments below .
Figure 4 Two types of compaction strength and the density of compacted particles under different models of anhydrous calcium hydrogen phosphate
→ It can be seen from Figure 4 that in different models of anhydrous calcium hydrogen phosphate, under the same compaction strength, A60 can produce denser particles
.
Figure 5.
Recompressibility of anhydrous calcium hydrogen phosphate compacted granules
→ Calculate the recompressibility (or reprocessing potential) of the particles from the area under the compression curve
.
→ It can be seen from Figure 5 that among the different models of anhydrous calcium hydrogen phosphate, A60 has relatively better reprocessing potential
.
Customers of direct compression and dry granulation processes are welcome to apply for free samples .
We will contact you as soon as possible to recommend and mail samples for you
.
Company Name: Shenzhen Youpuhui Pharmaceutical Co.
, Ltd.
Contact number: 18126405453