DCR: Botulinum toxin injection plus topical diltiazem can treat chronic anal fissures

Anal fissure (anal fissure) is a digestive tract from the dentate line to split the outlet surface of this narrowest anus anal tissue, the formation of small ulcers, a direction parallel to the longitudinal axis of the anal canal, spindle-shaped or oval, ca.
0.
5～1.
0cm, often cause severe perianal pain
.

Chemical sphincterotomy has become a promising method for the treatment of idiopathic chronic anal fissure (CAF)

Anal fissure (anal fissure) is a digestive tract from the dentate line to split the outlet surface of this narrowest anus anal tissue, the formation of small ulcers, a direction parallel to the longitudinal axis of the anal canal, spindle-shaped or oval, ca.

 

This is a randomized, controlled, double-blind trial with long-term follow-up
.

A total of 70 consecutive patients were referred to the gastroenterology department of a hospital in Valencia, Spain for this treatment

 

The results of the study showed that 13 (52%) of 25 patients in the diltiazem group and 11 (36.
7%) of 30 patients in the placebo group achieved final healing (p = 0.
25)
.

Anal pressure in both groups was significantly reduced

 

The results of this study confirm that botulinum toxin injection combined with topical diltiazem is not superior to botulinum toxin injection in the treatment of chronic anal fissure
.

The long-term recurrence rate is high (>80% at 10 years) and may appear at any time after healing

The results of this study confirm that botulinum toxin injection combined with topical diltiazem is not superior to botulinum toxin injection in the treatment of chronic anal fissure

 

Original source:

Herreros, Belen.

Botulinum Toxin Injection Plus Topical Diltiazem for Chronic Anal Fissure: A Randomized Double-Blind Clinical Trial and Long-term Outcome in this message