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    Home > Active Ingredient News > Digestive System Information > DCR: Drainage amylase as a biomarker for the detection of anastomotic leakage after ileal pouch surgery

    DCR: Drainage amylase as a biomarker for the detection of anastomotic leakage after ileal pouch surgery

    • Last Update: 2022-05-10
    • Source: Internet
    • Author: User
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    Anastomotic leakage (AL) is the most dangerous complication of colorectal surgery and, therefore, repair with an ileal pouch after proctoectomy has become the surgical option of choice


    Anastomotic leakage (AL) is the most dangerous complication of colorectal surgery and, therefore, repair with an ileal pouch after proctoectomy has become the surgical option of choice


     

    This is a multicenter prospective observational cohort study of selected patients from 4 tertiary hospitals in Queensland, Australia, all of whom underwent restorative proctectomy and ileal pouch surgery, and the researchers measured the patient's rectum.


     

     

    The results of the study showed that 4 of the 53 patients included in this study had an early anastomotic leakage with a median drainage amylase of 21897 U/L on the day of anastomotic leakage, while the drainage group without anastomotic leakage had a median of 21897 U/L.


    statistics

    Figure: Differences in the content of amylase in the drainage fluid of different patients

     

    This study demonstrates that the measurement of drainage fluid amylase is a sensitive biomarker of early clinical anastomotic leakage in patients undergoing ileal pouch repair proctectomy and uncomplicated transfer ileostomy


    This study demonstrates that the measurement of drainage fluid amylase is a sensitive biomarker of early clinical anastomotic leakage in patients undergoing ileal pouch repair proctectomy and uncomplicated transfer ileostomy


     

    Original source:

    Clark, David.


    Multicenter Study of Drain Fluid Amylase as a Biomarker for the Detection of Anastomotic Leakage After Ileal Pouch Surgery Without a Diverting Ileostomy.


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