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After colorectal excision, oral leakage (AL) remains the most serious postoperative complication, with rates ranged from 1% to 19%.
Risk factors for matching mouth leakage include male, age, ASA score, kidney failure, steroid use, immunosuppression, duration of surgery, sepsis in surgery, total colonectomy and partial colonectomy, blood transfusion and inadequate oral blood supply, etc.
blood is a recognized risk factor for matching mouth leakage, and cell-based therapy has increasingly been recognized as a new treatment for isoemia diseases.
Among these potential cell sources, there is increasing research into interstate stem cells (MSCs) because of their ability to separate from adult donor and maintain cell culture, where fat stem cells (ASCs) are superior to bone marrow stem cells.
study aims to study the role of fat stem cells in the healing of isoemia diseases. method
: The researchers first isolated fat stem cells from the off-skin fat of a healthy human body, and then performed abdominal surgery on rats to construct a isoemia colon matching mouth model, and the animals were divided into three parts: a control group with an ishemic matching mouth, only a gelatin sponge treatment group with local isoemia, and an ishemosis matching group with absorbable gelatin sponge plus fat stem cells.
the rats on the 3rd day after the operation (POD3) and the 7th day after the operation (POD7).
main observation indicator: the appearance of intestinal fluid in the matching mouth.
results showed that fat stem cells significantly reduced the occurrence of matching mouth leakage, and the occurrence of POD3 and POD7 matching mouth fistula was significantly lower (25% vs. 87.5%, p s 0.02) compared to the control group.
The use of absorbable gelatin sponges alone had no effect on the occurrence of matching leaks, and the researchers also found that angiogenesic factor (VEGF) expression increased 5.9 and 7.4 times in fatty stem cell-treated animals.
, the researchers concluded: Locally transplanted fat stem cells can promote the healing of ischemic bowel tubes, possibly as a new strategy to reduce the risk of mouth leakage during colorectal surgery.
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