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    Home > Active Ingredient News > Digestive System Information > DDS: Early rapid infusion therapy was associated with an increase in noninvasion positive pressure air rate in patients with severe acute pancreatitis.

    DDS: Early rapid infusion therapy was associated with an increase in noninvasion positive pressure air rate in patients with severe acute pancreatitis.

    • Last Update: 2020-09-18
    • Source: Internet
    • Author: User
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    Severe acute pancreatitis (SAP) can lead to multiple organ failure with a mortality rate of up to 36-50%.
    The most common of these is respiratory dysfunction, and although we have made many advances in the pathophysiology of acute pancreatitis (AP), there is still no effective drug treatment, fluid resuscitation is considered the cornerstone of early treatment AP, but there are many outstanding questions about how to rapidly recover fluid, so this study aims to investigate the relationship between blood cell prosthesis and early rapid fluid therapy (ERFT) and clinical outcomes in AP patients.
    reviewed the treatment of patients with SAP and defined the "fast" infusion speed as 3 ml/kg/h.
    the patients were divided into 4 groups for comparison: Group A, blood cell ratio of 44%, body fluid rate of 3 ml/kg/h;B, blood cell ratio of 44%, infusion rate of 3 ml/kg/h; C group, blood cell ratio of 44%; 44%, infusion speed of 3 ml/kg/h;D group, blood cell ratio of 44%, infusion speed of 3 ml/kg/h.
    outcome is the non-invasing positive pressure pass rate (NPPV).
    , a total of 912 consecutive AP patients were analyzed.
    ERFT had no effect on clinical outcomes in patients with blood concentration, non-severe or all non-blood concentration APs.
    in patients with severe AP (SAP) blood concentration, ERFT was associated with an increased risk of NPPV (OR:5.96, 95% CI 1.57-22.6).
    multivariate regression analysis confirmed that ERFT and blood drug concentrations in SAP patients were significantly and independently associated with persistent organ failure and mortality.
    , we can conclude that ERFT is associated with an increase in the rate of NPPV in blood-concentrated SAP patients.
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