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We know that the incidence of obesity and non-alcoholic fatty liver disease (NAFLD) is increasing, and while liver fat degeneration is usually more likely to occur in obese patients, it remains to be seen whether liver fat lesions can also occur in lean meat patients who do not have typical risk factors.
, in this study, the researchers aimed to determine the incidence and risk factors of liver fat degeneration in thin patients.
the researchers retrospectively collected thin patients with no viral hepatitis and a BMI of 25 kg/m2, and measured liver hardness measurement (LSM) and controlled attenuation parameters (CAP) using transient elastic imaging.
218 patients were included in the study, of which 34.5% showed liver fat degeneration (CAP-268 desebels/m) and higher glutyl-transpeptidease (GGT) in liver fatty degeneration patients (238.0 vs.112.1IU/mL; p= 0.013), AST (-63(±67.4)) vs.38.5 (±32.9) IU / mL; p=0.001) and ALT (59.1 (±58.8)vs. 44.3 (±52.7)IU / mL; p s 0.048) is also higher and shows a trend towards more severe fibrosis (LSM 15.6 (±19.5)vs. 12.0 (±15.7) kPa; p=0.11 5), in the multiregression analysis, only serum uric acid levels were independently associated with liver fat degeneration (OR 1.43 / mg / dL per unit; 95% CI 1.001-2.054; p - 0.049).
14 patients (5.0%) died during an average follow-up period of 38.9 months.
patients with no fat degeneration (98.7%) and fat degeneration (98.6%) had similar survival rates after one year without advanced fibrosis.
levels of serum uric acid increase the risk of liver fat degeneration in lean patients, the researchers concluded.
fibrosis rather than liver fatty degeneration are risk factors for loss of survival in thin patients.
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