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Death or non-death under stress is determined by the regulation of MK2 protein levels

 Last Update: 2021-07-29
 Source: Internet
 Author: User

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Figure: Diagram showing the mechanism of action of MK2 as a stress sensor that determines cell fate

Organisms are often exposed to stress stimuli produced by external or internal factors, and they need to respond accordingly

Scientists led by Dr.

Dr.

When cells are exposed to high levels of stress, the p38-MK2 pathway is activated in a continuous manner to promote the degradation of MK2 protein, which is related to cell death

"Using human and mouse cell lines to treat different stress stimuli, we showed that the expression level of MK2 is affected by the stress intensity, and they emphasize that the viability of the cells is crucial," explained Dr.

P38, a protein related to stress and cancer

P38 is a central protein that regulates many cellular processes by regulating the activity of many other proteins

Further research will investigate whether the p38-MK2 pathway acts as a common sensor for irreversible damage in cell types in response to strong or sustained stress

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Death or non-death under stress is determined by the regulation of MK2 protein level

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Death or non-death under stress is determined by the regulation of MK2 protein levels

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Death or non-death under stress is determined by the regulation of MK2 protein level