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    Home > Delimitation of quality standard for ultramicro decoction pieces of traditional Chinese Medicine

    Delimitation of quality standard for ultramicro decoction pieces of traditional Chinese Medicine

    • Last Update: 2018-01-18
    • Source: Internet
    • Author: User
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    Delimitation of quality standard for ultramicro decoction pieces of traditional Chinese Medicine According to the material characteristics of traditional Chinese medicine, the ultra micro comminution technology and energy consumption of traditional Chinese medicine, the correlation between the comminution method and the comminution machinery, the correlation between the comminution particle size and the chromatographic fingerprint characteristics and the stability of chemical components, the particle size range of various powders was determined, the process parameters of ultra micro comminution of traditional Chinese medicine with different positions and textures were formulated, and the comminution of traditional Chinese medicine powder was established General rule Take rhubarb for example (1) Correlation between the dissolution and fingerprint of rhubarb powder with different particle size The fingerprint of rhubarb powder was established The results showed that the retention time of rhubarb powder with different particle size was basically the same, but the difference of peak area was large With the increase of retention time, the peak area of different particle size increased, the smaller the particle size was, the larger the peak area increased, which indicated that the dissolution effect of fat soluble components was excellent In water soluble ingredients 2) Study on the correlation between bacteriostatic activity of rhubarb powder with different particle size and in vitro Mic was used as the index to study the bacteriostatic activity of rhubarb powder with different particle size The results of bacteriostatic diameter showed that there was obvious bacteriostatic effect between ultramicro and traditional pieces of rhubarb, and the relationship between concentration C of sample solution and DT / DS showed that the bacteriostatic effect of micro powder of rhubarb was better than that of traditional pieces of rhubarb 2 Establish the quality evaluation of raw materials for the quality standard of ultramicro decoction pieces of traditional Chinese medicine (the source of traditional Chinese medicine meets the national legal standards, and the heavy metal, arsenic salt and agricultural residues meet the Chinese pharmacopoeia or standards, The quality evaluation of the intermediate (ultra micro powder) (including particle size detection, specific surface area and bulk density, angle of repose and moisture absorption, inspection items and index component content determination), the quality evaluation of the finished product (including micro and thin layer identification, index component content determination, dissolution inspection, etc.), and the establishment of ultra micro decoction pieces of traditional Chinese Medicine Standardized quality standards (1) The specific surface area, bulk density and repose angle of powder with different particle size were measured by bt-1500 powder characteristics tester The results showed that the bulk density and repose angle of powder increased after micronization, indicating that the fluidity of ultrafine powder was lower than that of ordinary powder, and the specific surface area was larger than that of ordinary powder As shown in Table 1 (2) Particle size detection method laser diffraction phase method was used to determine the particle size, particle size distribution and specific surface area of the powder; micro image method was used to observe the surface morphology, micro cell structure and morphology, cell fracture degree of different particle size powder; cell count method was used to analyze the cell wall breaking rate ① Winner3001 new dry powder laser particle size method Due to the complexity of the material land of traditional Chinese medicine, the laser particle sizer with sedimentation method and solvent dispersion will often cause the larger particles of traditional Chinese medicine to settle or the smaller particles to dissolve with the extension of time Therefore, the dry dispersion method is more suitable for the measurement of the particle size of traditional Chinese medicine powder The results are shown in Table 2 The results show that the repeatability, authenticity, ease of operation and measurement range are all in line with the requirements of the test ② Study of powder characteristics Compared with the fine powder, the microscopic characteristics of the ultra-fine powder of traditional Chinese medicine were reduced, and the length and width of cells and tissues were significantly reduced Taking rhubarb as an example, after ultra-fine comminution, the cell wall was torn and disconnected, and most of the contents were comminuted into fragments, only the broken calcium oxalate clusters and scattered catheter fragments were found The diameter of starch granules was 3-18 μ M ③ Determination of cell wall breaking rate The micro characteristic cell count method was used to determine the cell wall breaking rate of the micro powder The cell wall breaking rate of the plant traditional Chinese medicine was more than 80%, and most varieties were more than 90% ④ The cell wall breaking rate was correlated with the particle size and dissolution rate The wall breaking rate of plant cells was used as the evaluation index, and the fineness was only used as a macroscopic detection index The results showed that: rhubarb powder (D90: 113.25 μ m, wall breaking rate: 35.5%), rhubarb powder 1 (D90: 72.12 μ m, wall breaking rate: 52.7%), rhubarb powder 2 (D90: 48.35 μ m, wall breaking rate: 90.2%), rhubarb powder 3 (D90 is 25.2 μ m, wall breaking rate is 100%) The relationship between the dissolution rate of rhubarb is that micropowder 1 ≈ micropowder 2 ≈ micropowder 3 > micropowder.
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