Demystifying the pathogenesis of aortic dissection from the perspective of single cells——The research results of Zhang Tao's research group from the Department of Vascular Surgery, Peking University People's Hospital are published in an authoritative academic journal

Recently, new discoveries have been made about the pathogenesis of aortic dissection (AD)

Innovative research articles published in Theranostics journals focus on in vitro diagnostics and prognosis, in vivo molecular imaging, molecular therapy, image-guided therapy, biosensors, systems biology and translational medicine, personalized medicine, and a wide range of biomedical research areas, which can be applied to Future Therapeutic Diagnostic Applications

Aortic dissection (AD), which can occur at any age, is one of the most common, complex and dangerous aortic diseases in clinical practice

The aorta is the largest arterial vessel and is divided into three layers: adventitia, media and intima.

According to studies, the pathogenesis of AD is mainly based on the abnormal structure of the medial membrane, that is, the degeneration of smooth muscle cells

Zhang Tao's group focuses on exploring cell-to-cell interactions and functional targets in vascular homeostasis and disease development

This study proves the feasibility of treating AD from the perspective of regulating the interaction between cells, which not only provides a new idea for the treatment of AD in the future, but also finds a new target for the drug treatment of AD in the future, that is, inhibition of fibroblasts.

Some research data and graphs

This research was supported by the National Natural Science Foundation of China and the National Key R&D Program Fund Project

Attachment: Author brief introduction

Zhang Tao, Chief Physician, Associate Professor, Doctoral Supervisor, Assistant of the Department of Vascular Surgery, Peking University People's Hospital