Basal cell carcinoma (BCC) is one of the most common skin tumors, most basal cell carcinomas occur in the head and neck, and although they rarely metastasize (<0.
1%), they can be locally aggressive and have high recurrence rate
Pathological biopsy remains the gold standard for diagnosis; however, with the development and increasing use of topical, intralesional, photodynamic, laser, and radiation therapy, and more recently hedgehog inhibitors, non-invasive diagnostic methods may be challenged favor
High-frequency ultrasound (e.
, ≥15 MHz) has high definition and penetrability, and can produce clear images, so it is considered a first-line imaging technique for the evaluation of non-melanoma skin cancers
Basal cell carcinoma appears on ultrasound as a hypoechoic dermal or subdermal structure of various shapes, often containing tumor hyperechoic spots
The purpose of this article was to evaluate the performance of high-frequency ultrasound in assessing BCC in order to develop recommendations for its use and to conduct a systematic review of the relevant literature
Central, Medline, Embase, CINHAL and Web of Science were searched by computer using the search terms "B-ultrasound" and "Basal Cell Carcinoma" (January 2005-December 2020)
High-frequency ultrasound provides accurate depth measurements, especially for BCCs >1 mm
The definition of the in vivo medial margin requires further study; however, the in vitro margin assessment seems convincing
Overall, high-frequency ultrasound accurately assessed the depth of the BCC
Among studies that specifically compared ultrasound depth and histopathology, 6/7 studies reported a moderate to high correlation
Source: Laverde-Saad A, Simard A, Nassim D,, Performance of Ultrasound for Identifying Morphological Characteristics and Thickness of Cutaneous Basal Cell Carcinoma: A Systematic Review.
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