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    Home > Active Ingredient News > Drugs Articles > Description of the process steps for the application of the crystallization, filtration, washing and drying integrated machine to the purification and purification of amoxicillin

    Description of the process steps for the application of the crystallization, filtration, washing and drying integrated machine to the purification and purification of amoxicillin

    • Last Update: 2022-09-09
    • Source: Internet
    • Author: User
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    The products produced by the existing domestic amoxicillin process have small average particle size, high coefficient of variation, high impurity residues and poor product stability
    .

    The advantages of the integrated crystallization, filtration, washing and drying machine used in the purification and purification process of amoxicillin are: less colored impurities, high yield of amoxicillin, good product quality, and at the same time, the recovery of qualified styrene ethyl suan, which is easy to be applied in production
    .

    The following editor briefly introduces the process steps of the crystallization, filtration, washing and drying integrated machine applied to the purification and purification of amoxicillin, as follows: (1) Extraction step The reaction solution is cooled, and then dichloromethane is added
    .

    Under stirring condition, adding mass concentration is 20~30% hydrochloric acid, separates dichloromethane phase; Carry out secondary extraction and tertiary extraction, finally obtain the extraction water phase containing 6-APA, and merge dichloromethane phase; ( 2) Amoxicillin reaction preparation step Add ammonia water to the extraction water phase containing 6-APA, at room temperature, remove the residual dichloromethane in the extraction water phase under reduced pressure; the obtained solvent removal 6-APA solution is subjected to pressure reduction.
    Filtration and concentration; synthesis reaction and separation to obtain amoxicillin crude product; step (3) acidifying and dissolving in the main shaft of the crystallization, filtration, washing and drying all-in-one machine, and adding 20-30% hydrochloric acid to the amoxicillin crude product to make amoxicillin Moxicillin is completely dissolved, and then filtered; (4) Under cooling conditions, add ammonia water with a mass concentration of 6 to 10% to the amoxicillin solution, control the pH of the feed liquid to be 4.
    8 to 5.
    2, and keep under cooling conditions.
    (5) Suction filtration, washing and drying The amoxicillin crystal solution was suction filtered by the crystallization filtration washing and drying multi-function machine, washed with purified water and acetone respectively, and then the amoxicillin wet powder was washed with Vacuum low-temperature drying, the temperature is 40-60 DEG C, the vacuum degree is ≥0.
    085MPa, and after drying, the amoxicillin dry powder is obtained
    .
     
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