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(6) Liquid chromatography-mass spectrometry (LC-MS)
Generally in multi-residue analysis, especially in liquid-mass spectrometry analysis, lincosamides and MALs can be analyzed at the same time, and it can meet the requirements of veterinary drug residue analysis, which greatly improves sample throughput and reduces laboratory exposure.
The amount of work processed
.
Thompson et al.
established the LC-Atmospheric Pressure Chemical Ionization (APCI)-MS method to detect lincomycin and tylosin in honey
.
Using a reversed-phase chromatography C 8 analytical column, the mobile phases were 0.
1% trifluoroacetic acid - acetonitrile and 0.
1% trifluoroacetic acid-water, gradient elution mode, flow rate 0.
5mL/min
.
In the mass spectrometry conditions, the probe temperature is 550°C, and the ion source temperature is 150°C
Bogialli et al.
established a simple and rapid confirmation method to detect three MALs in eggs
.
This analytical method only requires one step of acetonitrile extraction to perform LC-MS/MS detection
Aguilera-Luiz et al.
reported the simultaneous detection of 18 veterinary drugs (including MALs, quinolones and sulfonamides) in milk using UPLC-MS/MS
.
This method only needs to be extracted once through acetonitrile without any purification steps.
Chiaochan et al.
established an LC-MS/MS detection method for multiple drugs in chicken (including 2 lincosamide drugs and 4 MALs)
.
2% TCA water-acetonitrile mixture (1+1, v/v) was used for extraction, and LC-MS/MS analysis was performed after n-hexane degreasing
Liu Yongtao other aquatic established in quinocetone , olaquindox LC-MS / MS method for the simultaneous determination and 5 MALS
.
Use acetonitrile-10mmol/L ammonium formate solution as mobile phase, flow rate of 0.
Dubois et al.
also established an LC to simultaneously detect 5 MALs residues in tissues (muscle, liver, kidney), eggs, and milk, including tilmicosin, tylosin, erythromycin, spiramycin, and josamycin.
ESI-MS/MS method
.
Purospher C 18 column was used for separation, 0.
Related Links: Determination of Macrolides and Lincosamide Drug Residues-High Performance Liquid Chromatography