Determination of suitable heat sealing parameters for pharmaceutical soft plastic packaging bags

Abstract: the setting of heat sealing parameters directly affects the heat sealing strength of the soft plastic packaging bag for drug packaging The heat sealing strength is an important physical and mechanical performance index of the soft plastic packaging bag for drug packaging Through the description of the determination process of the suitable heat sealing parameters of a granular drug packaging bag, this paper introduces a method of determining the heat sealing parameters for the majority of users, and provides a reference for the enterprise to solve the problem of the poor heat sealing strength of the packaging bag caused by the improper setting of the heat sealing parameters The test equipment used in the test is ghs-03 double five point thermal seal gradiometer and XLW (PC) intelligent electronic tensile tester produced by Jinan Languang Electromechanical Technology Co., Ltd Key words: heat sealing parameters, heat sealing strength, heat sealing strength, sealing strength, dual five point heat sealing gradiometer, intelligent electronic tensile testing machine, medicine, soft plastic packaging, medicine packaging 1, significance Heat sealing strength refers to the sealing fastness of the heat sealing edge of soft plastic packaging, also known as heat sealing strength and sealing strength Its strength value is directly related to heat sealing parameters such as heat sealing temperature, heat sealing pressure and heat sealing time If the setting of heat sealing parameters is too low, the heat sealing layer is difficult to really integrate, the heat sealing strength is low, and the problems such as cracking and air leakage are easy to occur at the sealing place, and the phenomenon of wire drawing is easy to occur when cutting the bag, which affects the beauty of the packaging bag; if the setting of heat sealing parameters is too high, the heat sealing place is easy to shrink, and even causes the undercutting problem at the heat sealing place of the packaging bag, which causes the packaging to be easy to be sealed in the heat sealing place Broken bag at root Therefore, it is of great significance to determine the appropriate heat sealing parameters Fig 1 medical soft plastic packaging roll film 2 At present, there is no relevant standard on how to determine the heat sealing parameters of soft plastic packaging in China This paper is based on the American Standard ASTM f2029-2008 test method for determining the heat sealing performance of soft plastic packaging by measuring the heat sealing strength 3 Test sample: aluminum coated composite film for packaging of certain brand granular medicine 4 This paper involves two kinds of testing equipment, ghs-03 dual five point thermal seal gradiometer and XLW (PC) intelligent electronic tensile testing machine Both of the testing equipment are independently developed and produced by Jinan Languang Electromechanical Technology Co., Ltd Fig 2 ghs-03 double five point thermal sealing gradiometer Fig 3 XLW (PC) intelligent electronic tensile testing machine 4.1 test principle the basic principle of the whole test is that the sample is heat sealed under different heat sealing parameters, and the appropriate heat sealing parameters of the sample are determined according to the surface state and heat sealing strength value after heat sealing 4.1.1 ghs-03 double five point thermal sealing gradiometer this equipment uses the method of hot pressing sealing to heat seal the sample By setting the parameters of heat sealing pressure, heat sealing time and heat sealing temperature, the sample is heat sealed The equipment has five independent heat sealing heads, which can control the temperature separately 4.1.2 the XLW (PC) intelligent electronic tensile testing machine has two clamps, the upper clamp can move up and down, and the lower clamp is fixed During the test, the sample is clamped between two clamps, and the two clamps move relative to each other The force value and displacement changes in the test process are collected by the force value sensor on the dynamic chuck and the displacement sensor built in the machine, so as to calculate the final test results of Zui 4.2 scope of application (1) ghs-03 dual five point thermal sealing gradiometer is applicable to the thermal sealing test of various plastic films, plastic composite films, paper plastic composite films, CO extrusion films, aluminum coating films, aluminum foil, aluminum plastic composite films and other film-like materials Through special customization, the equipment can also be used for the heat sealing test of container materials such as jelly cup cover and plastic hose Meet a number of national and international standards, such as QB / T 2358, ASTM f2029, ybb00122003 (2) XLW (PC) intelligent electronic tensile testing machine is suitable for testing heat sealing strength, tensile property, tensile strength and deformation rate, tensile breaking force, tear resistance, 90 degree peel, 180 degree peel and other properties After special customization or fixture, the equipment can also be used to test the puncture force of infusion bag cover, the puncture or drawing force of soft rubber bottle stopper and oral liquid cover, the pulling force of infusion bag cover, the unwinding force of adhesive tape, the pulling force of makeup brush and toothbrush brush, the tearing force of sealing film and other packaging and product performance It meets a number of national and international standards, including more than 20 domestic and foreign relevant standards such as ISO 37, GB / T 2790, GB / T 2791, GB / T 10004, GB 8808, GB / T 1040.1 ~ GB / T 1040.4, GB / T 1040.5, QB / T 2358, QB / t 1130, ASTM d882, ASTM D1938, ASTM d3330, etc 4.3 equipment parameters (1) the control range of heat seal temperature of ghs-03 double five point heat seal gradiometer is room temperature ~ 250 ℃, temperature control accuracy is ± 0.2 ℃; the control range of heat seal pressure is 0.1MPa ~ 0.7MPa; the setting range of heat seal time is 0.1 ~ 999.9s Digital p.i.d temperature control technology can not only achieve the set temperature quickly, but also effectively avoid temperature fluctuations Two test start modes of manual and pedal as well as anti scald design can effectively ensure the convenience and safety of users The equipment can complete five groups of heat sealing tests at a time, and accurately obtain the heat sealing performance parameters of the sample The five upper heads are respectively controlled by five cylinders to ensure the stability of the heat sealing process The upper and lower heads can control temperature independently, providing users with more combinations of test conditions (2) Two kinds of force sensors of 500N and 50N of XLW (PC) intelligent electronic tensile testing machine are available, and the testing accuracy is 0.5 level According to the relevant standards, the equipment provides seven test speeds of 50 mm / min, 100 mm / min, 150 mm / min, 200 mm / min, 250 mm / min, 300 mm / min and 500 mm / min, which can be set freely according to the requirements of the test standards The ultra long stroke of 1000 mm can meet the test of materials with large deformation rate Intelligent configuration of limit protection, overload protection, automatic return and power failure memory can ensure the operation safety of users A testing machine integrates seven independent testing procedures, such as tension, peeling, tearing, etc., providing users with a variety of test options Support Lystem TM laboratory data sharing system, and manage test results and test reports in a unified way 5 During the test (1), 6 samples with length of 30 cm and width of 15 cm were cut from the sample surface (2) Open ghs-03 double five point heat sealing instrument, set the heat sealing pressure and time, the temperature of the lower heat sealing head can be set to a certain temperature or keep room temperature, and the heat sealing temperature of the upper heat sealing head can be set according to a certain temperature gradient (3) When the upper and lower heat sealing heads reach the set temperature, take two samples, stack them together (the two hot covers contact each other), and put the long side of the sample into the heat sealing instrument for heat sealing (4) Take the Zui high heat seal temperature of the upper heat head mentioned in (2) as the starting point, set the heat seal temperatures of five upper heat heads according to a certain temperature gradient, heat seal the samples according to the steps in (3), and so on until the completion of the heat seal of the samples (5) Two test strips with a width of 15 mm shall be cut from the heat sealing edge corresponding to each heat sealing temperature, and the development length of each test strip shall be at least 10 cm (6) Open the XLW (PC) intelligent electronic tensile testing machine, and set parameters such as sample width, test speed, etc (7) Clamp the sample strip between the upper and lower clamps, and the long axis direction of the sample strip coincides with the center line of the two clamps Click the test option to start the test After the test, the instrument automatically displays the test results Fig 4 test process Fig (8) repeat (7) until all test pieces are tested 6 Test results in this paper, the heat sealing pressure is set to 0.3MPa, the heat sealing time is 1s, the temperature of the lower heat sealing head is set to 100 ℃, the heat sealing temperature of the upper heat sealing head starts from 130 ℃, and increases with a temperature gradient of 5 ℃, that is, the high heat sealing temperature of Zui is 200 ℃ See Table 1 for the average value of heat sealing strength at each heat sealing temperature The test results of XLW (PC) intelligent electronic tensile testing machine are four decimal places, only two decimal places are reserved in this paper Table 1 heat seal strength test results heat seal temperature (℃) 130 135 140 145 150 155 160 165 170 175 180 185 190 195200 heat sealing strength (n / 15mm) 1.43 3.76 9.31 13.43 19.65 22.60 21.90 23.68 20.84 23.01 18.06 20.71 19.35 17.66 15.91 in the heat sealing process of the sample, when the heat sealing temperature is above 180 ℃, the heat sealing part of the sample shrinks Therefore, combined with the heat sealing strength value in Table 1, the Zui preferred heat sealing temperature range of the sample is 155 ℃ ~ 175 ℃ 。 7 Conclusion the heat sealing parameters have an important influence on the heat sealing strength of the medical soft plastic packaging Through ghs-03 double five point heat sealing gradiometer, XLW (PC) Two kinds of testing equipment of intelligent electronic tensile testing machine can quickly determine the Zui best heat sealing parameters of soft plastic packaging, which can avoid the production stoppage when exploring the heat sealing parameters on the packaging heat sealing machine, or the problems such as air leakage of the packaging bag and the increase of the bag breaking probability caused by improper setting of the heat sealing parameters Labthink Languang is always committed to providing professional testing equipment and services for customers around the world In addition to the above two types of testing equipment, Labthink Languang can also provide you with testing equipment of barrier performance, physical and mechanical performance, health performance and other categories of medical packaging For more information about the equipment, you can visit www.labthink. Com or call for advice The more you understand, the more you trust! Labthink is looking forward to enhancing technical exchanges and cooperation with enterprises and institutions in the industry!