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    Home > Biochemistry News > Biotechnology News > Determining Lipase Subunit Structure by Sucrose Gradient Centrifugation

    Determining Lipase Subunit Structure by Sucrose Gradient Centrifugation

    • Last Update: 2020-12-03
    • Source: Internet
    • Author: User
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    The lipase gene family comprises three vertebrate genes, lipoprotein lipase (LPL), hepatic lipase (HL) and pancreatic lipase (PL), that are derived from a common ancestral gene. While these lipases are functionally related, considerable evidence indicates that LPL and HL share a higher degree of structural homology than either shares with PL (
    1

    4
    ). For example, it has been established by a number of different methods that LPL and HL are functionally active as homodimers, while PL is active as a monomer (
    5

    9
    ). However, there are discrepancies reported in the literature, namely the findings of monomeric functional units of LPL and HL by Ikeda et al. (
    10
    ) and Schoonderwoerd et al. (
    11
    ), the latter concluding that the functional unit of rat HL in the liver is a monomer, while in adrenal gland and ovary it might be a dimer.
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