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The lipase gene family comprises three vertebrate genes, lipoprotein lipase (LPL), hepatic lipase (HL) and pancreatic lipase (PL), that are derived from a common ancestral gene. While these lipases are functionally related, considerable evidence indicates that LPL and HL share a higher degree of structural homology than either shares with PL (
1
–
4
). For example, it has been established by a number of different methods that LPL and HL are functionally active as homodimers, while PL is active as a monomer (
5
–
9
). However, there are discrepancies reported in the literature, namely the findings of monomeric functional units of LPL and HL by Ikeda et al. (
10
) and Schoonderwoerd et al. (
11
), the latter concluding that the functional unit of rat HL in the liver is a monomer, while in adrenal gland and ovary it might be a dimer.