Dev Cell: Unsaturated fatty acids can fight cancer? Cell Press exclusively declassified potential mechanism "Iron Death"

!---- As more and more people realize the importance of health care, most people are increasingly choosing to consume unsaturated fats instead of saturated fats to reduce their risk of cardiovascular diseaseU.Sdietary guidelines recommend that if unsaturated fats are used instead of saturated fat, you consume less than 10 percent of your total calorie intake, a recent study in Cell Press looked at the relationship between cell iron, dgla-linoleic acid (DGLA) and endogenous ether lipids in reproductive cells and human cancer cells, starting with the mechanism of "iron death."and proposed a potential treatment for cancer, that is, the use of DGLA-specific induced iron death characteristics, the external DGLA combined with small molecule iron-induced death induction agents to kill cancer cellsdoi: 10.1016/j.devcel.2020.06.019, what is iron death? Ferroptosis, first proposed in 2012, is an iron-dependent form of non-apoptotic cell death characterized by a large accumulation of iron ions and lipid peroxidation in the process of cell deatha large number of studies have found that Ferroptosis is closely related to neurological diseases, tumors, ischemic reperfusion injury diseases, kidney damage and iron metabolism diseasesiron death mechanism II, ferroptosis and DGLA and endogenous ether in the diet between lipids can affect growth and development, stable state of the body and certain diseases, but little is known about the link between fat in the diet and cell fatthe study: DGLA can induce Ferroptosis and infertility in the reproductive cells that trigger nematodes, Celegans, and specifically induce Ferroptosis in human cancer cellswhen the supplementation of endogenous ether lipids prevents iron-dependent cell deathfound that ferroptosis and apoptosis were activated during co-treatment with ThedGLA with polyunsaturated fatty acids and antioxidant inhibitors ferrostatin-1 (Fer-1), and That Fer-1 completely reversed the infertility of The Ced-3 mutants caused by DGLA, suggesting that DGLA could induce Ferroptos in reproductive cells of CelegansFer-1 regulates DGLA-induced reproductive cell death of course, we are most concerned about the effects of DGLA on human cancer cells, and the study found that DGLA may have induced Ferroptosis by directly regulating the membrane phosphatidylationthe DGLA-induced death process is longer than the small molecule cystein blocker erastin, possibly because cells need to absorb fatty acids and donot it into cell phospholipids in order to function(A) cell death over time; (B) heat map showing that 6 hours after DGLA (500 or 250 mM) growth with ethanol control, the relative multiplier variation of various lipid fatty acid compositions, based on the relationship between polyniaps and iron death, suggested that DGLA combined with small molecule iron death inducer, can induce cancer cells and other sensitive cells in the body Ferroptosis, which may be an effective treatment of cancer potentialscientists still have a long way to go in preventing and effectively treating cancerin general, dietary polyunsaturated fatty acids are closely related to health and have important research valueat the same time, physical health is not only associated with a balanced diet, but also with quality sleep, regular exercise, regular physical examination and so on.