Devel Cell: Chemotherapy preparations may have the opposite effect on the overgrowth of normal tissues in the body

22, 2020 // -- In a recent study published in the international journal Developmental Cell, scientists from Vanderburg University and other institutions reported an intuitive finding that specific chemotherapy preparations used to treat tumors may have normally complete breasts, epiderfs, and hairs. Overgrowth of cystic tissue has the opposite effect, and in the article, researchers first found that a congenital immune signaling path path in fibroblasts, a spindle-like cell that is primarily responsible for wound healing and collagen production, may promote cell proliferation in fibroblasts, which researchers previously believed existed only in immune cells.
: Seldin researchers say the findings are important for treating a variety of immune system diseases, cancer and stem cell research, such as psoriasis. 'Understanding the function of stem cells and the way they regulate their behavior has always been an area of interest to me,' said Lindsey Seldin, a researcher at
. 'Normal stem cells have an amazing ability to continuously divide and maintain tissue function, but they don't form tumor tissue, so we want to study what happens when these are damaged in the natural environment, and whether this reaction is associated with a particular presence.'
The researchers observed a paradoxical response by detecting fluctuations and effects of mechanical or DNA damage from chemotherapy agents on the body's epiderma, breast tissue, and hair follicles, i.e. stem cells that split slowly themselves began to divide rapidly and continue to promote tissue overgrowth.
when tissue is damaged by DNA, stem cells over-proliferate and produce different cell types than normal, which may be a phenomenon and result that researchers can't understand.
the researchers wanted to study whether the phenomenon was a direct reaction to stem cells themselves or an induced signal in their environment.
The key clue is that stem cells isolated from the body do not behave the same way as they do in intact tissue, suggesting that the reaction must have been caused by signals sent to stem cells by other surrounding cell types;
RNA sequencing results suggest that fibroblasts may be able to send signals through inflammatory small bodies, and that complexes in cells can help tissues respond to stress by cleaning up damaged cells or pathogens, in which case stem cell division may be a surprising finding, the researchers said, noting that inflammatory small body signals were previously thought to be only associated with immune cells, but now we find that fibroblasts may also have immune-like properties.
The next step is for researchers to repeat the study in the body's breast tissue to determine whether fibroblasts open up the same congenital immune response process in epiderptic tissue, and to clarify how fibroblasts contribute to the development of cancer and other diseases associated with the immune system.
original source: Lindsey Seldin, Ian G. Macara.DNA Damages Epithelial Hyperplasia and Fate Mis-specification via Fibroblast Inflammasome, Activation Developmental Cell (2020). DOI: 10.1016/j.devcel.2020.09.021