Di- and Oligonucleotide Synthesis Using H-Phosphonate Chemistry
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Last Update: 2021-03-06
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Source: Internet
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Author: User
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In this chapter, a concise account of the synthesis of oligonucleotides using the
H
-phosphonate methodology is given. It includes various methods for the preparation of the starting material, nucleoside 3′-
H
-phosphonate monoesters, their conversion into dinucleoside
H
-phosphonate diesters, oxidative transformations of dinucleoside
H
-phosphonates into the corresponding phosphate and phosphorothioate derivatives, and protocols for the synthesis of oligonucleotides and their phosphorothio analogs.
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