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    Home > Biochemistry News > Biotechnology News > Di- and Oligonucleotide Synthesis Using H-Phosphonate Chemistry

    Di- and Oligonucleotide Synthesis Using H-Phosphonate Chemistry

    • Last Update: 2021-03-06
    • Source: Internet
    • Author: User
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    In this chapter, a concise account of the synthesis of oligonucleotides using the
    -phosphonate methodology is given. It includes various methods for the preparation of the starting material, nucleoside 3′-
    -phosphonate monoesters, their conversion into dinucleoside
    -phosphonate diesters, oxidative transformations of dinucleoside
    -phosphonates into the corresponding phosphate and phosphorothioate derivatives, and protocols for the synthesis of oligonucleotides and their phosphorothio analogs.
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