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The incidence of diabetes worldwide has quadrupled over the past few decades, with type 2 diabetes accounting for 90%
.
Although cardiovascular diseases (CVDs) remain the leading cause of death in patients with T2DM, a considerable portion of the disease burden cannot be explained by traditional cardiovascular risk factors
The incidence of diabetes worldwide has quadrupled over the past few decades, with type 2 diabetes accounting for 90%
Clinical studies have noted an increased incidence of cobalamin deficiency in diabetic patients, especially in metformin users, because metformin inhibits cobalamin absorption
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This study included 3277 adults with T2DM from the National Health and Nutrition Examination Survey (NHANES) and followed up until December 31, 2015
.
Hazard ratios (HRs) and 95% CIs for the risk of death were estimated using weighted Cox proportional hazards regression
Among 3277 participants, 865 all-cause deaths occurred during a median follow-up of 7.
02 years
.
Overall, there was no strong relationship between all-cause mortality and intake of serum cobalamin or food or cobalamin supplements regardless of metformin treatment (P ≥ 0.
Overall, there was no strong relationship between all-cause mortality and intake of serum cobalamin or food or cobalamin supplements regardless of metformin treatment (P ≥ 0.
However, doubling of methylmalonic acid (MMA), a marker of cobalamin deficiency, was associated with a 31% higher all-cause mortality (HR= 1.
Cobalamin sensitivity was assessed by a combination of binary B12 low/high and MMA low/high (cutoff values: cobalamin 400 pg/mL, MMA 250 nmol/L)
.
Patients with reduced cobalamin sensitivity (high MMA and high B12) had the highest risk of death
The HRs (95%CI) for all-cause mortality in the low MMA low B12, low MMA high B12, high MMA low B12low, and high MMA high B12 groups were 1.
CONCLUSIONS: Serum and dietary cobalamin were not associated with a reduction in mortality
Cobalamin Intake and Related Biomarkers: Examining Associations With Mortality Risk Among Adults With Type 2 Diabetes in NHANES .
Cobalamin Intake and Related Biomarkers: Examining Associations With Mortality Risk Among Adults With Type 2 Diabetes in NHANESLeave a Comment here
