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According to the World Health Organization ( WHO ), the unhealthy life>to an explosive increase in the prevalence of T2DM in China over the past 20 years .
Both overweight and obesity are risk factors for T2DM .
.
Both overweight and obesity are risk factors for T2DM .
At the same time, nearly half of the adults in China, about 500 million people, are currently in pre-diabetes
.
This not only increases the chance of developing T2DM , but also the risk of developing other diseases such as cardiovascular disease .
A study recently conducted by experts from the Shanghai Institute of Nutrition and Health of the University of Chinese Academy of Sciences and the Sixth People's Hospital affiliated to Shanghai Jiaotong University suggested that a healthy life>
At the same time, nearly half of the adults in China, about 500 million people, are currently in pre-diabetes
Melatonin is a hormone secreted in large amounts at night or in low light, and its main function is to regulate the sleep - wake cycle
The researchers conducted a randomized, crossover study in a Spanish natural late eater population
.
Each participant ( n=845 ) underwent two evening 2 -hour 75 g oral glucose tolerance tests after an 8 -hour fast: 4 hours before bedtime and 1 hour before bedtime ( " late dinner time " ) to simulate early and late Dinner time .
The area under the curve ( AUC ) calculated by the trapezoidal method was used to determine the difference in postprandial glucose and insulin responses between the early and late dinners .
The researchers conducted a randomized, crossover study in a Spanish natural late eater population
The results showed that melatonin serum levels were 3.
5 times higher when eating late compared to eating early, and eating late resulted in a 6.
7% decrease in insulin AUC (assessing islet beta cell function) and an 8.
Meanwhile, the effect of impaired glucose tolerance was stronger in MTNR1B G-allele carriers than in non-carriers
CONCLUSIONS: The typical late eating pattern of elevated endogenous melatonin levels and carbohydrate intake, especially in MTNR1B G allele carriers, impairs glycemic control, attributable to defective insulin secretion
.
CONCLUSIONS: The typical late eating pattern of elevated endogenous melatonin levels and carbohydrate intake, especially in MTNR1B G allele carriers, impairs glycemic control, attributable to defective insulin secretion
references:
Interplay of Dinner Timing and MTNR1B Type 2 Diabetes Risk Variant on Glucose Tolerance and Insulin Secretion: A Randomized Crossover Trial .
Diabetes Care 1 March 2022; 45 (3): 512–519.
Interplay of Dinner Timing and MTNR1B Type 2 Diabetes Risk Variant on Glucose Tolerance and Insulin Secretion: A Randomized Crossover Trial .
Diabetes Care 1 March 2022; 45 (3): 512–519.
https://doi.
org/10.
2337/dc21- 1314 Interplay of Dinner Timing and MTNR1B Type 2 Diabetes Risk Variant on Glucose Tolerance and Insulin Secretion: A Randomized Crossover Trial Leave a Comment here