Diabetes Care: blood sugar control, diabetes complications and dementia risk in diabetic patients

Type 2 diabetes is a known risk factor for dementia
.
However, the role of blood sugar control and diabetic complications in the development of dementia has not been proven

Recently, a research article was published in Diabetes Care, an authoritative journal in the field of diabetes.
This large-scale cohort study aims to explore the relationship between longitudinal glycosylated hemoglobin levels and diabetes complications and the incidence of dementia in patients with type 2 diabetes
.

The researchers analyzed the data of eligible diabetic patients aged ≥50 years in the UK clinical practice research data link from 1987 to 2018, and used time-varying Cox regression to estimate adjusted hazard ratios (HRs) and 95% CI for the risk of dementia
.

Among the 457,902 diabetic patients, during a median follow-up of 6 years, the researchers found 28,627 (6.
3%) cases of dementia
.
And no hypoglycemic events or micro vascular compared to patients with complications, patients with a higher risk of hypoglycemia or microvascular complications of dementia (HR were 1.

It can be seen that higher or unstable HbA1c levels and diabetic complications are associated with increased risk of dementia in patients with type 2 diabetes
.
Effective blood sugar control may be important for maintaining the cognitive health of elderly diabetic patients