Recently, a randomized, multi-site clinical trial evaluated a single diabetic ketoacidosis (DKA) and whether the onset of a new diagnosis of type 1 diabetes in children's cognitive decline related to, and in consideration of glycemic control and other relevant factors After the change, whether the same is true for previously diagnosed children, the results of the study have been published in Diabetes Care
The researchers prospectively recruited 758 children with DKA between the ages of 6-18 and evaluated the intravenous infusion regimen for DKA treatment
430 children had moderate/severe DKA, and 328 children had mild DKA
A total of 392 children with DKA were newly diagnosed with type 1 diabetes, and the rest were previously diagnosed
The patient’s neurocognitive function was evaluated 2-6 months after the onset of DKA
The comparison group consisted of 376 children with type 1 diabetes but no DKA
As a result, in all patients, moderate/severe DKA was associated with lower intelligence quotient (IQ) (β = -0.
12, P <0.
001), item color recall (β = -0.
08, P = 0.
010), and forward numerical span (β = -0.
06, P = 0.
Among newly diagnosed patients, moderate/severe DKA was associated with lower item color recall (β=-0.
In previously diagnosed patients, repeated DKA exposure and higher HbA1c were independently associated with lower IQ (β = -0.
10 and β = -0.
09, respectively, P <0.
01), adjusted for hypoglycemia , diabetes duration, and social After economic conditions, higher HbA1c correlated with lower item color recall (β = -0.
10, P = 0.
In summary, a single episode of DKA is associated with a slight memory decline shortly after the diagnosis of type 1 diabetes
A higher degree of IQ decline can be detected in children with known diabetes, which indicates that the effects of DKA in children who are exposed to hyperglycemia for a long time may be exacerbated
Simona Ghetti, et al.
, Cognitive Function Following Diabetic Ketoacidosis in Children With New-Onset or Previously Diagnosed Type 1 Diabetes .
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