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Glycated hemoglobin (HbA1c) is a clinically recognized standard for monitoring blood glucose control.
It is linearly related to the average blood glucose concentration in the past 2-3 months.
It is a useful tool for monitoring long-term blood glucose control in diabetic patients
.
Prevention of micro associated with chronic hyperglycemia vascular complications, is a major therapeutic goal
Glycated hemoglobin (HbA1c) is a clinically recognized standard for monitoring blood glucose control.
In type 1 and type 2 diabetes, there is a clear relationship between HbA1c and the risk of microvascular complications
However, the use of HbA1c has important limitations
To study the glucose changes associated with HbA1c in insulin-treated type 2 diabetes (T2D) patients, the results of the study were published in the journal Diabetes Care
.
The researchers enrolled in DIALECT-2 patients (n = 79) were divided into three HbA1c categories: low, medium, and high (respectively ≤53, 54-62 and ≥63mmol/mol or ≤7, 7.
The results showed that the median (IQR) of CGM was 10 (7-12) days/patient
.
There was no difference in TIR between the low-level and intermediate HbA1c categories (76.
There was no difference in TIR between the low-level and intermediate HbA1c categories (76.
The median values of TIR, TBR1, TBR2, TAR1 and TAR2 are divided into HbA1c≤53 mmol/mol, HbA1c 54-62 mmol/mol and HbA1c≥63 mmol/mol
.
Patients in the highest HbA1c category had lower TIR (52.
7% [40.
9-67.
3]) and higher TAR (44.
1% [27.
8-57.
0]) than patients in other HbA1c categories, but there was no reduction in TBR at night
.
All patients had more (0.
Patients in the highest HbA1c category had lower TIR (52.
In this study, high HbA1c did not reduce the occurrence of nighttime hypoglycemia, and low HbA1c was not associated with the highest TIR
references:
Glucose Regulation Beyond HbA1c in Type 2 Diabetes Treated With Insulin: Real-World Evidence From the DIALECT-2 Cohort.
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