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Observational studies have shown that women with type 2 diabetes are a stronger risk factor for coronary heart disease (CHD) than men.
, however, it is not clear whether this reflects a causal gender difference between diabetes and coronary heart disease risk, or whether it is due to a mix of gender specificity.
researchers used 270 single nucleotide polymorphisms (SNPs) for type 2 diabetes identified in the type 2 diabetes genome-wide association study, and used data from individual participants at Biobank UK (251,420 women and 212,049 men) to conduct a gender-stratification Mendel randomized (MR) study of type 2 diabetes and CHD patients.
weighted median, MR-Egger, MR multi-effect residual sum and outliers, and MR in summary level analysis are used for multi-efficiency evaluation.
MR analysis showed that for women (the risk of type 2 diabetes increased by 1 pair unit, the ratio ratio was 1.13 (95% CI is 1.08-1.18)) and men (1.21 (1.17-1.26)) the genetic risk of type 2 diabetes increased the risk of CHD.
sensitivity analysis found some evidence of targeted multi-effects.
, the results were similar after the SNP outlier was corrected.
, this MR analysis supports a causal relationship between the genetic effects of type 2 diabetes on CHD risk and is no stronger for women than for men.
that these assumptions are not published, these results suggest that the prevention and control of type 2 diabetes aimed at reducing the risk of CHD is equally important in both male and female patients.
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