Diabetes Care: How do biomarkers related to blood glucose, lipid metabolism, and inflammation change in the first 20 years of type 1 diabetes diagnosis?

Type 1 diabetes accounts for 99% of all diabetes in children and adolescents, and it is worth noting that a recent study based on UK biobank data estimated that 42% of cases were diagnosed in patients between the ages of 30 and 60 of
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Research on the pathogenesis of adult-onset type 1 diabetes is limited, but it has been shown that adults typically have only one autoantibody, while children tend to be positive for multiple autoantibodies

Diabetic children and adults with type 1 diabetes usually have only one autoantibody, whereas children tend to be positive for multiple autoantibodies

Diagnosis This study assessed whether elevated blood glucose, lipids, and other biomarkers are associated with future risk of type 1 diabetes in adults

The researchers analyzed 591,239 individuals from the Swedish AMORIS cohort from 1985-1996-2012
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The incidence of type 1 diabetes was determined through links with national patient, diabetes and prescription registers

The researchers analyzed 591,239 individuals from the Swedish AMORIS cohort from 1985-1996-2012

The results of the study showed that a total of 1122 patients with type 1 diabetes were identified during the follow-up period (mean age of patients at diagnosis: 53.

Trajectories of biomarker values ​​20 years before type 1 diabetes diagnosis

Biomarker value trajectories 20 years before type 1 diabetes diagnosis Biomarker value trajectory 20 years before type 1 diabetes diagnosis Biomarker value trajectories20 years before type 1 diabetes diagnosis value track

Briefly, altered levels of biomarkers related to blood glucose, lipid metabolism, and inflammation were associated with clinically diagnosed type 1 diabetes risk, and these levels may be elevated many years before diagnosis
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Briefly, altered levels of biomarkers related to blood glucose, lipid metabolism, and inflammation were associated with clinically diagnosed type 1 diabetes risk, and these levels may be elevated many years before diagnosis
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Briefly, altered levels of biomarkers related to blood glucose, lipid metabolism, and inflammation were associated with clinically diagnosed type 1 diabetes risk, and these levels may be elevated many years before diagnosis

References: Katharina Herzog, Tomas Andersson, Valdemar Grill, Niklas Hammar, Håkan Malmström, Mats Talbäck, Göran Walldius, Sofia Carlsson; Alterations in Biomarkers Related to Glycemia, Lipid Metabolism, and Inflammation up to 20 Years Before Diagnosis of Type 1 Diabetes in Adults: Findings From the AMORIS Cohort.
Diabetes Care1 February 2022; 45 (2): 330–338.
https://doi.
org/10.
2337/dc21-1238 References: Katharina Herzog, Tomas Andersson, Valdemar Grill, Niklas Hammar , Håkan Malmström, Mats Talbäck, Göran Walldius, Sofia Carlsson; Alterations in Biomarkers Related to Glycemia, Lipid Metabolism, and Inflammation up to 20 Years Before Diagnosis of Type 1 Diabetes in Adults: Findings From the AMORIS Cohort.
Diabetes Care 1 February 2022; 45 (2): 330–338.
https://doi.
org/10.
2337/dc21-1238 References: Katharina Herzog, Tomas Andersson, Valdemar Grill, Niklas Hammar, Håkan Malmström, Mats Talbäck, Göran Walldius, Sofia Carlsson; Alterations in Biomarkers Related to Glycemia, Lipid Metabolism, and Inflammation up to 20 Years Before Diagnosis of Type 1 Diabetes in Adults: Findings From the AMORIS Cohort.
  Diabetes Care  1 February 2022; 45 (2): 330–338.
  https ://doi.
org/10.
2337/dc21-1238Katharina Herzog, Tomas Andersson, Valdemar Grill, Niklas Hammar, Håkan Malmström, Mats Talbäck, Göran Walldius, Sofia Carlsson; Alterations in Biomarkers Related to Glycemia, Lipid Metabolism, and Inflammation up to 20 Years Before Diagnosis of Type 1 Diabetes in Adults: Findings From the AMORIS Cohort.
  Diabetes Care Diabetes Care  1 February 2022; 45 (2): 330–338.
  https://doi.
org/10.
2337/dc21-1238 Leave a comment here