Diabetes Care: Long-term changes and variability in blood sugar in people with type 2 diabetes associated with heart failure risk

A recent study published in Diabetes Care, an authoritative journal ofdiabetes, looked at the long-term changes and variability of blood sugar in patients with type 2 diabetes (T2DM) and the association between heart failure (HF)in the T2DM participants who participated in the ACCORD experiment, the researchers assessed the variability of HbA1c by the degree of stability of HbA1c between the participants' group (8 months) and follow-up for 3 years, as follows: average continuous variability (ASV) (continuous value), coefficient of variation (SD/average), and SDParticipants with HF within 3 years of baseline or entry were excludedThe adjusted Cox model is used to assess the correlation between the percentage change of HbA1c in the first 3 years of the group (3 years from baseline to follow-up) and HbA1c variability and HF riskthe study included 8,576 patientsDuring the 6.4-year median follow-up period from the end of the variability measurement, 388 patients were hospitalized with HFChanges in HbA1c were significantly correlated with higher risk of HF (a risk ratio of 1.32 for a reduction of 10% (95% CI is 1.08-1.75) and an increase of 10% risk ratio was 1.55 (1.19-2.04); HbA1c change reference value of 10%)The larger Long-Term Variability of HbA1c was associated with a higher risk of HF (ASV had a risk ratio of 1.34 for every change in 1 SD (95% CI was 1.17-1.54) and was not associated with changes in baseline risk factors and cardiac metabolic parametersConsistent association patterns can be observed using alternative blood glucose variabilityit can be seen that long-term changes and variability of HbA1c are independently associated with HF risk in Patients with T2DM