Diabetes Care: n-3 fatty acid biomarkers and the risk of type 2 diabetes

In a single study, the prospective association between n-3 fatty acid biomarkers and type 2 diabetes (T2D) risk was not consistent.

Recently, a research article was published in Diabetes Care, an authoritative journal in the field of diabetes.
Researchers aim to summarize α-linolenic acid (ALA), eicosapentaenoic acid (EPA), and 22 Prospective associations between biomarkers such as carbpentaenoic acid (DPA) and docosahexaenoic acid (DHA) and T2D risk.

The researchers included data from 20 prospective studies from 14 countries, a total of 65147 participants without diabetes at baseline, and measured their blood levels of ALA, EPA, DPA or DHA.
Re-analysis was performed in each cohort according to a preset plan, and the inverse variance weighted meta-analysis was used to aggregate cohort-specific correlations.

A total of 16693 T2D events were identified during the follow-up period (median follow-up range was 2.
5 to 21.
2 years).
In summary multivariate analysis, each quintile range (the difference between the 90th and 10th percentile of each fatty acid), EPA, DPA, DHA and their sum and comparison The low incidence of T2D is associated with a hazard ratio (HR) and 95% CI of 0.
92 (0.
87-0.
96), 0.
79 (0.
73-0.
85), 0.
82 (0.
76-0.
89), and 0.
81 (0.
75-0.
88) (all P<0.
001) ).
Within each quintile range, ALA and T2D (HR 0.
97 [95% CI 0.
92-1.
02]) are not correlated.

It can be seen that higher circulating levels of n-3 fatty acids (including EPA, DPA, DHA and their sum) derived from seafood are associated with lower T2D risk, while plant-derived ALA is not significantly correlated with T2D risk .
Original source: Frank Qian,et al.
org/10.
2337/dc20-2426" target="_blank" rel="noopener">n-3 Fatty Acid Biomarkers and Incident Type 2 Diabetes: An Individual Participant-Level Pooling Project of 20 Prospective Cohort Studies .
Diabetes care.
2021.
https://doi.
org/10.
2337/dc20 -2426
  
org/10.