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    Home > Active Ingredient News > Endocrine System > Diabetes Care: Relationship between manganese and plasma inflammatory markers in diet and type 2 diabetes in postmenopausal women

    Diabetes Care: Relationship between manganese and plasma inflammatory markers in diet and type 2 diabetes in postmenopausal women

    • Last Update: 2020-06-25
    • Source: Internet
    • Author: User
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    A recent study in Diabetes Care, an authoritative journal of diabetes, looked at the relationship between manganese intake in postmenopausal women and the risk of type 2 diabetes and whether the association was mediated by circulating inflammatory markersresearchers included 84,285 postmenopausal women with no history of diabetes in the National Women's Health Program Observation Study (WHI-OS)Repeated analysis was then performed in 62,338 women who participated in the WHI-CTIn addition, the researchers evaluated case-control data from 3,749 women with biomarker information about inflammation and endothelial dysfunction in the WHI-OS trial and identified the relative contribution of these known biomarkers to the risk of manganese-affected type 2 diabetesthe highest risk of type 2 diabetes was reduced by 30% for one-fifth of WHI-OS participants compared to those with the lowest energy-adjusted diet of one fifth of the total ( the risk was 0.70 compared to .95% CI 0.65-0.76) compared to the lowest one-fifth of the participants in the energy-adjusted dietConsistent associations are also obtained in WHI-CT (HR is 0.79 (95% CI is 0.73-0.85)In the nest case control study, the higher manganese intake in the energy-adjusted diet was associated with lower levels of inflammatory biomarkers in the cycle, while the levels of inflammatory biomarkers significantly correlated manganese intake in the diet and the risk of type 2 diabetesSpecifically, 19% and 12% of the risk of type 2 diabetes caused by manganese are mediated by interleukin 6 and hs-CRP, respectivelyit is clear that higher manganese intake is directly related to a lower risk of type 2 diabetes and not to known risk factorsThis association may be mediated by an inflammatory biomarker
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