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Hyperuricemia is a necessary pre-process of gout.
As part of the insulin resistance syndrome, hyperuricemia and gout are both associated with an increased risk of cardiometabolic diseases and premature death.
Schematic diagram of gout
Schematic diagram of goutUsually, doctors recommend that patients with hyperuricemia or gout follow a low-purine (ie, low-protein) diet to reduce the purine load.
A low-purine diet can lead to increased intake of refined egg carbohydrates and unhealthy fats.
In the long term, a low-purine diet may not be healthy.
To this end, experts from Harvard University Medical School and Massachusetts General Hospital conducted a comprehensive study on the effects of three common weight-loss diets on lowering uric acid and cardiovascular disease risk, and the results were published in the journal Diabetes Care.
The secondary study of this randomized controlled trial of dietary intervention (DIRECT) used a stored sample of 235 moderately obese participants who were randomly assigned to low-fat, restricted energy intake (low-fat group, n = 85); Mediterranean, restricted Energy intake ( Mediterranean diet group, n=76); or low-carbohydrate, unrestricted energy intake (low-carbohydrate group, n=74) diet.
Mediterranean diet
The researchers followed up the participants' overall body weight and uric acid changes at 6 months (short-term) and 24 months (long-term), as well as changes in uric acid levels in hyperuricemia participants (uric acid ≥416 μmol/L).
Changes of uric acid during the follow-up period of the participants in the three diet weight loss groups
Changes of uric acid during the follow-up period of the participants in the three diet weight loss groupsIn all subjects, the average unit reduction of uric acid at 6 months and 24 months was 48 μmol/L and 18 μmol/L, respectively.
The average unit reduction of uric acid at 6 months and 24 months was 48 μmol/L and 18 μmol/L, respectively.
Low-carb and high-protein diets have a better effect of lowering uric acid, even better than low-protein diets.
Changes in cardiovascular and metabolic factors during the follow-up period of participants in the three diet weight loss groups
Changes in cardiovascular and metabolic factors during the follow-up period of participants in the three diet weight loss groupsRegarding the cardiovascular metabolic risk, the three groups of body weight, high-density lipoprotein cholesterol (HDL-C), total cholesterol: HDL-C ratio, triglyceride and insulin concentration all improved.
Changes in body weight and fasting plasma insulin concentration are still related to changes in blood glucose levels.
In summary, a non-low-purine weight loss diet can also improve diabetes and cardiovascular risk factors by reducing obesity and insulin resistance .
references:
diabetesjournals.
diabetesjournals.
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