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Diabetes Care: The new hypoglycemic drug imiglitazone effectively improves HbA1c in patients with type 2 diabetes

 Last Update: 2021-04-13
 Source: Internet
 Author: User

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Type 2 diabetes (T2DM) is a widespread disease, with more than 500 million people suffering from T2DM worldwide .

The incidence of T2DM is increasing.

Imiglitazone is the first new type of oral anti-diabetic research drug for the treatment of T2DM.

The basic mechanism of imiglitazone involves targeting the biological characteristics of mitochondria and improving mitochondrial function.

This is a double-blind, randomized, parallel-group, placebo-controlled phase 3 trial conducted at 30 medical centers in Japan.

Screening

Patients were randomly assigned (1:1) to oral imiglitazone (1000 mg twice a day) or a matching placebo for 24 weeks.

Between December 26, 2017 and February 1, 2019, 106 and 107 patients were randomly assigned to treatment with imiglitazone and placebo, respectively.

Compared with placebo, the adjusted mean difference in HbA1c changes from baseline at week 24 was -0.

Compared with the placebo group (8/106 [7.

Forty-seven patients (44.

In summary, compared with placebo, imiglitazone can significantly improve HbA1c in Japanese T2DM patients, and its safety is similar to placebo.

Compared with placebo, imiglitazone can significantly improve the HbA1c of Japanese T2DM patients, and its safety is similar to that of placebo.

references:

diabetesjournals.

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