Diabetes Care: The relationship between folic acid, vitamin B6, and vitamin B12 intake is associated with the incidence of diabetes.

A recent study published in Diabetes Care, an authoritative journal of diabetes, aims to pre-evaluate the correlation between folic acid, vitamin B6 and vitamin B12 intake and diabetes incidence.
1985-1986, 4,704 U.S. adults between the ages of 18 and 30 without diabetes participated in the Youth Coronary Artery Risk Development Study (CARDIA) and were monitored between 2015 and 2016.
dietary assessments were conducted at baseline, 1992-1993 and 2005-2006 through valid dietary history questionnaires.
the cumulative average intake of folic acid, vitamin B6 and vitamin B12 for analysis.
researchers determined the incidence of diabetes by plasma glucose levels, oral glucose tolerance tests, hemoglobin A1c concentrations, and/or blood sugar-lowering drugs.
655 cases of diabetes occurred during 30 years of follow-up (average 20.5 to 8.9).
adjusted for potential confounding factors, folic acid intake instead of vitamin B6 or vitamin B12 was negatively associated with the incidence of diabetes.
the multi-variable adjusted risk ratio of 2-5 in the pentatric sepsis (95%CI) was 0.85 (0.67-1.08), 0.78 (0.60-1.02), 0.82 (0.62-1.09) and 0.70 (0.51-0.97; trend P.02), respectively, compared to the lowest quintile of total folic acid intake. Higher intake of folic acid in
was also associated with plasma homocysteine levels (trend P-lt;0.01) and insulin levels (trend P-lt;0.01).
in supplement users, folic acid intake is inversely proportional to serum C-reactive protein levels (trend P.lt;0.01).
it can be seen that folic acid intake in young age is negatively correlated with the incidence of middle-aged diabetes. the associations observed in
may be explained in part by mechanisms associated with high cysteine levels, insulin sensitivity, and systemic inflammation.
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