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    Home > Active Ingredient News > Endocrine System > Diabetes Care: The relationship between SGLT2 inhibitors and the risk of retinal vein occlusion in patients with type 2 diabetes

    Diabetes Care: The relationship between SGLT2 inhibitors and the risk of retinal vein occlusion in patients with type 2 diabetes

    • Last Update: 2021-07-30
    • Source: Internet
    • Author: User
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    Recently, a research article published in Diabetes Care, an authoritative journal in the field of diabetes , used data from the National Health Insurance Service of Korea to evaluate the use of sodium-glucose cotransporter 2 (SGLT2) inhibitors and retinal vein occlusion (RVO).
    )
    .

    diabetes


     
    The researchers used national data from 2014 to 2017, based on a 1:1 propensity score match, and included 47369 new users of SGLT2 inhibitors and 47369 users of other glucose-lowering drugs (oGLD)
    .
    In the matched sample, the researchers used the Cox proportional hazards model to estimate the risk ratio (HR) and 95% CI for RVO


    .


    During the 2.
    57-year follow-up period, the incidence of RVO in patients treated with SGLT2 inhibitors and oGLD was 2.
    19 and 1.
    79 per 1,000 people per year, respectively


    .


    Survival curve

    In the subgroup analysis, the researchers observed a significant interaction between age and estimated glomerular filtration rate (eGFR) and SGLT2 inhibitors; RVO in patients over 60 years of age and eGFR<60mL/min/1.
    73m2 HR is higher than other patients
    .


     


    Researchers found that SGLT2 inhibitors are associated with a significant increase in the risk of RVO
    .
    Elderly patients with chronic kidney disease and higher risk RVO original source: Sodium-Glucose cotransporter 2 Inhibitors and Risk of Retinal Vein Occlusion Among the Type 2 Patients With Diabetes: A Propensity Score-Matched Cohort Study In this message
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