Diabetes Care: There are differences in the composition and function of the intestinal flora of children with type 1 diabetes, MODY2 and healthy controls

Diabetes is due to the absolute or relative lack of insulin secretion, which leads to disorders in the metabolism and utilization of blood sugar
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Studies have shown that changes in the structure and function of the intestinal flora are closely related to hyperglycemia and insulin resistance.

Intestinal flora and its related metabolites play an important role in the pathology and physiology of type 2 diabetes, such as blood glucose metabolism, insulin resistance, and chronic inflammation.

This article will talk about the relationship between diabetes and intestinal flora
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Purpose: Type 1 diabetes is related to differences in the composition of intestinal flora
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So far, there have been no microbiological studies on adult-onset diabetes (MODY2) in young people, which is a type of diabetes with single-gene genetic mutations

Study design and methods: This is a case-control study, the subjects were 15 children with type 1 diabetes, 15 children with MODY2 and 13 healthy children
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Metabolism and potential factors affecting the intestinal flora are controlled

Results: Compared with the healthy control group, the diversity of type 1 diabetic patients' flora was significantly reduced, the relative abundance of Bacteroides, ruminant cocci, Weironella, Brucella and Streptococcus was significantly increased, and bifidobacteria The relative abundances of Lilium rosea, faecalis faecalis and Spirulina lacrimal were significantly reduced
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MODY2 has a higher abundance of Prevotella, and a lower abundance of ruminant cocci and Bacteroides

The branch diagram shows the different abundance taxa of type 1 diabetes, MODY2 and healthy control fecal microflora
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Use linearity test for discriminant analysis and effect size analysis

(Kruskal-Wallis test, P=0.
05), to verify the statistical significance and effect size of the differences in taxa abundance in each study group
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The diameter of each circle is proportional to its abundance

  Conclusion: The intestinal flora of type 1 diabetic patients is not only different from healthy subjects in taxonomy and functional level, but also fundamentally different in non-autoimmune diabetes models
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Future longitudinal studies can evaluate whether the regulation of the intestinal flora of high-risk patients with type 1 diabetes can change the natural history of this autoimmune disease

The intestinal flora of patients with type 1 diabetes is not only different from healthy subjects in taxonomy and functional levels, but also fundamentally different in non-autoimmune diabetes models

 

Leiva-Gea I, Sánchez-Alcoholado L, Martín-Tejedor B, et al.

Gut Microbiota Differs in Composition and Functionality Between Children With Type 1 Diabetes and MODY2 and Healthy Control Subjects: A Case-Control Study

 

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