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Diabetes Care: Trans fatty acid biomarkers and the onset of type 2 diabetes: a pooled analysis of 12 prospective cohort studies in the Consortium for Fatty Acids and Outcomes Research (FORCE)

 Last Update: 2022-03-05
 Source: Internet
 Author: User

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OBJECTIVE: Trans fatty acids (TFAs) have deleterious biological effects that increase the risk of type 2 diabetes (T2D), but the evidence is inconclusive
.

Our aim was to investigate the prospective association of TFA biomarkers and T2D by performing a pooled analysis at the individual participant level

Trans fatty acids (TFAs) have deleterious biological effects that increase the risk of type 2 diabetes (T2D), but the evidence is inconclusive

RESULTS: During a mean follow-up period of 13.
5 years, a total of 2843 T2D cases were identified
.

In a multivariate adjusted pooled analysis, trans-18:2 was not significantly associated with T2D, with a relative risk (RR) of 1.

Table 1 Determination of type 2 diabetes in 10 prospective cohort studies

Figure 1 summarizes the relative risk of type 2 diabetes by quintile interval (difference between the midpoints of the 1st and 5th quantiles in trans-16:1n9)
.

The association between trans-16:1n-9 and type 2 diabetes was assessed by a multivariate model adjusted for age, sex, race, venue (if applicable), education, occupation, physical activity, smoking, alcohol consumption, hypertension , dyslipidemia, coronary heart disease, body mass index, waist circumference, circulating palmitic acid, circulating stearic acid, circulating linoleic acid and triglycerides

Figure 1 summarizes the relative risk of type 2 diabetes by quintile interval (difference between the midpoints of the 1st and 5th quantiles in trans-16:1n9)

Figure 2 summarizes the relative risk of type 2 diabetes by the quintile interval of total trans-18:1 (difference between the midpoints of the 1st and 5th quantiles)
.

The relationship between all-trans-18:1 and type 2 diabetes was assessed by a multivariate model adjusted for age, sex, race, venue (if applicable), education, occupation, physical activity, smoking, alcohol consumption, hypertension , dyslipidemia, coronary heart disease, body mass index, waist circumference, circulating palmitic acid, circulating stearic acid, circulating linoleic acid and triglycerides

Figure 2 summarizes the relative risk of type 2 diabetes by the quintile interval of total trans-18:1 (difference between the midpoints of the 1st and 5th quantiles)

Circulating individual trans-18:2 TFA biomarkers were not associated with T2D risk, whereas trans-16:1n-9, all-trans-18:1, and all-trans-18:2 were inversely associated

Trans Fatty Acid Biomarkers and Incident Type 2 Diabetes: Pooled Analysis of 12 Prospective Cohort Studies in the Fatty Acids and Outcomes Research Consortium (FORCE).
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