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    Home > Active Ingredient News > Endocrine System > Diabetes Care: Vitamin D status, vitamin D receptor polymorphisms, and risk of microvascular complications in patients with type 2 diabetes

    Diabetes Care: Vitamin D status, vitamin D receptor polymorphisms, and risk of microvascular complications in patients with type 2 diabetes

    • Last Update: 2022-10-12
    • Source: Internet
    • Author: User
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    Background: In 2015, there were an estimated 415 million people with diabetes worldwide, and the number is projected to rise to 642 million


    Objective: There is limited evidence on the relationship between vitamin D status and microvascular complications in individuals with type 2 diabetes mellitus (T2D), of which vitamin D deficiency or insufficiency is particularly common


    Study design and methodology: This analysis included 14,709 patients with


    Results: The median serum 25(OH)D concentration was 40.


    Table 1 Serum 25(OH)D concentrations of different VDR genotypes in T2D patients in the UK Biobank

    Table 2 Multivariate correction risk ratio (95% CIs) in the association between VDR polymorphisms and diabetes microvascular complications in patients with T2D in the UK Biobank

    Table 3 Risk ratio of multivariate correction for the relationship between serum 25(OH)D concentration and diabetic microvascular complications in patients with T2D (95% CIs) according to different genotypes of VDR polymorphisms

    Conclusion: Higher serum 25(OH)D concentrations are significantly associated


    Source: Chen X, Wan Z, Geng T,et al.


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