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Diabetes: Moristat-an exploration to save the hypoxic response of diabetic heart disease and reverse metabolic dysfunction!

 Last Update: 2021-12-02
 Source: Internet
 Author: User

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Heart vascular disease is diabetes, cause of death, even with optimal management of risk factors (blood sugar, blood pressure, cholesterol ), the risk of T2D patients suffering from cardiovascular disease is still a 21% increase

Healthy people researchers induced pluripotent stem cells (of hiPSC) lines IMR90 and cultured in M180 medium mTeSR1 matrix coating plate, separated by ReLeSR

The final experimental results show that type 2 diabetes (T2D) damages the activation of hypoxia-inducible factor (HIF) 1a, which is a major transcription factor that can promote the adaptation of cells to hypoxia

Molidustat stabilizes HIF1a signaling and downstream metabolic adaptation in human cardiomyocytes

In human cardiomyocytes, molidustat stabilizes HIF1a and downstream HIF target genes, and promotes anaerobic glucose metabolism

In short, drug stabilization of HIF1a can overcome the slow hypoxia response caused by insulin resistance

Maria da LuzSousa Fialho ,UjangPurnama ,Kaitlyn MJHDennis ,Claudia N.
Montes Aparicio , Marcos Castro-Guarda , Emmanuelle Massourides , Damian J.
Tyler , Carolyn A.
Carr , Lisa C.
Heather.
Maria da Luz Sousa Fialho Maria da Luz Sousa Fialho MariaSousa Fialho Ujang Purnama UjangPurnama Kaitlyn MJH Dennis Kaitlyn MJHDennis Claudia N.
Montes AparicioClaudia N.
Montes Aparicio Marcos Castro-Guarda Marcos Castro-Guarda Emmanuelle Massourides Emmanuelle Massourides Damian J.
Tyler Damian J.
Tyler Carolyn A.
Carr Carolyn A.
Carr Lisa C.
Heather.
Lisa C.
Heather.
Diabetes 2021, 70 (11 ) 2518-2531; DOI: 10.
2337/db21-0398 DOI: 10.
2337/db21-0398 DOI: Leave a message here

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