Diabetes: The relationship between blood sugar, cognitive function, structural brain outcomes, and dementia

Recently, a research article was published in Diabetes, an authoritative journal in the field of diabetes .
Researchers aim to use two-way Mendelian randomization (MR) to study the relationship between blood sugar and cognitive function, brain structure, and dementia events
.

The data for this study comes from the British Biobank (n=500000)
.

Through IVW, genetic susceptibility to type 2 diabetes and RT (index β=1.
00, 95%CI=1.
00; 1.
00), visual memory (VM) (expβ=1.
00, 95%CI=0.
99; 1.
00), white matter hyperintensity volume (WMHV) (expβ=0.
99, 95%CI=0.
97; 1.
01), hippocampal volume (HV) (β coefficient mm3=-2.
30, 95%CI=-12.
39;7.
78) or AD (OR=1.
15, 95%CI= 0.
87; 1.
52) irrelevant
.

HbA1c and RT (expβ=1.
00, 95%CI=0.
99; 1.
02), VM (expβ=0.
99, 95%CI=0.
96; 1.
02), WMHV (expβ=1.
03, 95%CI=0.
88; 1.
22), HV (β =-21.
31, 95%CI=-82.
96; 40.
34) or AD risk (OR 1.
09, 95%CI=0.
42; 2.
83) is irrelevant
.

Overall, the researchers did not observe evidence of a causal relationship between T2D or peripheral blood glucose genetic tools and middle-aged cognition and brain structure

Original source:

Victoria Garfield,et al.