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    Home > Active Ingredient News > Endocrine System > Diabetes: The relationship between blood sugar, cognitive function, structural brain outcomes, and dementia

    Diabetes: The relationship between blood sugar, cognitive function, structural brain outcomes, and dementia

    • Last Update: 2021-07-29
    • Source: Internet
    • Author: User
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    Recently, a research article was published in Diabetes, an authoritative journal in the field of diabetes .
    Researchers aim to use two-way Mendelian randomization (MR) to study the relationship between blood sugar and cognitive function, brain structure, and dementia events

    .

    diabetes

    The data for this study comes from the British Biobank (n=500000)
    .
    The exposure factors of the study were genetic tools for type 2 diabetes (157 variants) and HbA1c (51 variants).
    The outcome of the study was reaction time (RT), visual memory, hippocampal and white matter hyperintensity volume, Alzheimer’s Dementia (AD)

    .
    The researchers also explored the association between RT (43 variants) and genetic variants in diabetes and HbA1c

    .
    In addition, researchers use traditional inverse variance weighted (IVW) MR, as well as MR sensitivity analysis

    .

    Through IVW, genetic susceptibility to type 2 diabetes and RT (index β=1.
    00, 95%CI=1.
    00; 1.
    00), visual memory (VM) (expβ=1.
    00, 95%CI=0.
    99; 1.
    00), white matter hyperintensity volume (WMHV) (expβ=0.
    99, 95%CI=0.
    97; 1.
    01), hippocampal volume (HV) (β coefficient mm3=-2.
    30, 95%CI=-12.
    39;7.
    78) or AD (OR=1.
    15, 95%CI= 0.
    87; 1.
    52) irrelevant

    .

    HbA1c and RT (expβ=1.
    00, 95%CI=0.
    99; 1.
    02), VM (expβ=0.
    99, 95%CI=0.
    96; 1.
    02), WMHV (expβ=1.
    03, 95%CI=0.
    88; 1.
    22), HV (β =-21.
    31, 95%CI=-82.
    96; 40.
    34) or AD risk (OR 1.
    09, 95%CI=0.
    42; 2.
    83) is irrelevant

    .
    After excluding a pleiotropic variant, IVW showed that RT was not associated with diabetes risk (OR 0.
    94, 95%CI=0.
    54; 1.
    65) or HbA1c (β coefficient mmol/mol=-0.
    88, 95%CI=-1.
    88; 0.
    13)

    .

    Overall, the researchers did not observe evidence of a causal relationship between T2D or peripheral blood glucose genetic tools and middle-aged cognition and brain structure
    .

    Researchers have not observed evidence of a causal relationship between T2D or peripheral blood glucose genetic tools and middle-aged cognition and brain structure

    Original source:

    Original source:

    Victoria Garfield,et al.
    The Relationship Between Glycaemia, Cognitive Function, Structural Brain Outcomes and Dementia: A Mendelian Randomisation Study in the UK Biobank .
    Diabetes.
    2021.
    https://doi.
    org/10.
    2337/db20-0895

    The Relationship Between Glycaemia, Cognitive Function, Structural Brain Outcomes and Dementia: A Mendelian Randomisation Study in the UK Biobank

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