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    Home > Active Ingredient News > Endocrine System > Diabetogia: Cord blood metabolic markers are powerful regulators of maternal obesity's effect on fetal growth during pregnancy

    Diabetogia: Cord blood metabolic markers are powerful regulators of maternal obesity's effect on fetal growth during pregnancy

    • Last Update: 2020-06-25
    • Source: Internet
    • Author: User
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    The purpose of this study was to assess the relationship between cord blood metabolic markers and fetal overgrowth, and whether umbilical cord markers mediated the effects of maternal obesity on normal glucose tolerance (NGT), gestational diabetes (GDM) and neonatal anthropometric measurements in children born with pre-pregnancy type 2 diabetesin the Australian (PANDORA) pregnancy and neonatal outcomestudy study, 645 of the 1135 mother-to-child observation teams had intravenous blood cord blood for the only children with NGT (n s 129), GDM (n s 419) and type 2 diabetes (n s 97)The umbilical cord glucose, triglycerides, HDL cholesterol, c-reactive protein (CRP) and c peptides were measuredThe relationship between cord blood metabolism and birth weight z score, skin layer thickness sum (SSF), gestational age (LGA) and body fat percentage was analyzed using multivariate logistic and linear regressionThe link between maternal and neonatal obesity was used to analyze and evaluate whether the umbilical cord markers mediated the association between maternal and neonatal obesityafter adjusting age, race and diabetes types, umbilical cord C peptide stakes and birth weight z scores (beta 0.57 (95% CI0.42, 0.71), SS F (beta 0.83 (95% CI0.41, 1.25), body fat percentage (beta 1.20 (95% CI0.69, 1.71) and LGA risk (OR3.14 (95% CI2.11, 4.68)) were significantly correlatedTriamide was negatively correlated with the birth weight z score of Indigenous Australian womenUmbilical cord glucose, HDL cholesterol and CRP 0.3 mg/l (2.9nmol/l) were not associated with neonatal outcomesCpeptide-mediated 18% (95% CI13, 36) maternal BMI associated with LGA, 11% (95% CI8, 17) associated with neonatal fatresults show that cord blood cpeptide snr is an important intermediary between mother and child obesity in maternal sugar tolerance spectrum
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