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    Home > Active Ingredient News > Endocrine System > Diabetogia: Does the reduced sugar effect of alpha-glucosidase inhibitors require bile acid signals?

    Diabetogia: Does the reduced sugar effect of alpha-glucosidase inhibitors require bile acid signals?

    • Last Update: 2020-07-27
    • Source: Internet
    • Author: User
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    !---- the gut acid metabolism of the body balance (BA) signal is critical, and it has recently been found to mediate the efficacy of sugar-lowering therapy, including alpha-glucosidase inhibitors (AGI)however, the specific mechanisms involved have yet to be clarifiedwe assume that BA signals may be necessary for AGI's sugar-reducing effects and metabolic benefitsa wok (KO) db/db mice and High Fat High Sucrose (HFHS)-fed Fxr (also known as Nr1h4) KO mice with AGI for Lepr in this studyassessed metabolic episographs and BA signals at different sites, including the liver, internal organs and endocrine pancreasused mass spectrometry to analyze BAthe intestinal microbiome is detected by RNA sequencing analysis of islet transcription, 16S ribosome RNA gene sequencingAGI reduced microbial BA levels in BA pools in different body regions of the body and increased reabsorption of intestinal BA in db/db and hhbs feeding mouse models by altering the intestinal microbiomechanges in BA signals caused byAGI (including increased activation of the farnesoid X receptor (FXR) in the liver and inhibition of FXR in the reflux) echoed changes in ba pool size and composition in different organsin Fxr-KO mice, AGI's sugar-lowering and lipid-lowering effects were partially eliminated, possibly due to AGI's dependence on fxr, slowing cell replication, reducing insulin secretion, and improving liver lipid and glucose metabolismresults show that by regulating the metabolism of microbial BA, AGI causes various changes in BA pool composition in different host chambers, thus coordinating the transmission of BA signals throughout the bodyAGI-induced changes in BA signal conduction may be partly to blame for its sugar-lowering effects, our study reveals the potential to regulate microbial BA and host FXR signals in the treatment of type 2 diabetes.
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