Diabetogia: GLP-1 receptor agonision lixisenatide lowers post-meal blood sugar for diabetics after full pancreatic excision.
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Last Update: 2020-07-30
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Source: Internet
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Author: User
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The treatment of secondary diabetes remains a challenge after !---- whole pancreatic excision, and insulin is the only sugar-lowering treatment option for these patients.this study, it is assumed that the glucagon-like peptide 1 (GLP-1) receptor agonis lisisanite can improve post-meal glucose tolerance in patients with whole pancreatic excision.in a double-blind, randomized, cross-study, a total of 12 individuals who completely removed the pancreas after a single dose of 20?g lissila or a placebo (age: 65.0 x 9.5 average sD years; BMI: 22.9 x 3.9 kg / m2) and 12 healthy control individuals (66.1 x 7.6 years; BMI: 24.0 kg / m2) were tested for two three-hour liquid mixed meals (assessed gastric emptying with paracetamol).given underlying insulin the night before each experimental day;compared to placebo, lixisenatide reduced pancreatic excision group (baseline-subtracted AUC (bsAUC) (mean?SEM) : 548 s 125 vs 1447 x min, p.lt; 0.001) and control group (?126.12.222.51 mmol/l,pancreatic excision group had an average peak glucose concentration of 23.3 to 1.0 mmol / l in the 134-11 min group, while in the placebo group it was 18 x 1.4 mmol / l (p - 0.008) Lisilla for 148 to 13 minutes (p . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .in the control group, the average peak concentration of placebo at 70?13 min was 8.2 to 0.4 mmol / l, while the average peak concentration at the 8-hour point was 5.5 to 0.1 mmol / l (p.lt;0.001).25 minutes with Lisilla (p s li0.054).in the pancreatic excision group (66-group84 vs 1190-311 pmol / l x min, p - 0.008) and control group (141 x 100 vs 190 x 100 pmol / l x min, Lissesenatide also reduced the reaction of gastric draining and post-meal hyperglycemia, p. 0.034).c peptides were not detected in the plasma in the pancreatic group.control group, the post-meal plasma c peptide reaction was reduced with lisesiniti (18 x 17 vs 189 x 31 nmol/l x min, p.lt; 0.001).results showed that GLP-1 receptor agonists lixisenatide reduced the increase in blood sugar after meals in patients with whole pancreatic excision.its modes of action seem to include a slower rate of gastric emptying and a decrease in post-meal reactions of the visceral source glucagon..
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