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    Home > Active Ingredient News > Endocrine System > Diabetogia: Plasma tissue protease D activity in overweight and obese populations is negatively correlated with liver insulin sensitivity

    Diabetogia: Plasma tissue protease D activity in overweight and obese populations is negatively correlated with liver insulin sensitivity

    • Last Update: 2020-06-25
    • Source: Internet
    • Author: User
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    In the pathophysiology of type 2 diabetes, the insulin resistance of the skeletal muscle and liver plays an important roleThe high insulin-positive glucose clamp test is the gold standard for assessing insulin sensitivity around and in the liver, but it is expensive and time-consumingTherefore, an easy-to-measure and cost-effective method is needed to determine insulin sensitivity, making organ-specific intervention possibleRecently, there is evidence that plasma tissue protease D (CTSD) is associated with insulin sensitivity and liver inflammationHere, our goal is to study whether plasma CTSD is associated with human liver and/or peripheral insulin sensitivityas part of two large clinical trials (one to study the effects of antibiotics and the other to study the effects of polyphenol supplementation on insulin sensitivity), 94 overweight and obese adults (BMI 25-35 kg/m2) had previously received two-step hyperinsulinemia-wide insulin clamps (Using glucose of s6,6-2H2) to assess liver and peripheral insulin sensitivity (percentage of inhibition of endogenous glucose output during the low insulin infusion step, and glucose loss rate of 40m2x2)In this study, plasma CTSD levels, CTSD activity and plasma inflammatory cytokines were measuredstudies showed that plasma CTSD levels were positively correlated with the pro-inflammatory cytokines IL-8 and TNF-alpha (IL-8: Standardized beta-0.495, p-0.001; TNF-alpha: standardized beta 0.264, p-0.012)Plasma CTS D activity was negatively correlated with liver insulin sensitivity (standardized beta-0.206, p-0.043), not related to age, sex, BMI, and waist circumference, but not peripheral insulin sensitivityHowever, there was no significant correlation between plasma IL-8 and TNF-alpha and liver insulin sensitivitythe study found a negative correlation between plasma CTSD activity and liver insulin sensitivity, rather than systemic inflammation, suggesting that plasma CTSD activity could be used as a non-invasive index of human liver insulin sensitivity
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