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    Home > Active Ingredient News > Endocrine System > Diabetogia: The effect of weekly cysteine and daily canagretin on the body composition of people with type 2 diabetes?

    Diabetogia: The effect of weekly cysteine and daily canagretin on the body composition of people with type 2 diabetes?

    • Last Update: 2020-06-25
    • Source: Internet
    • Author: User
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    Intra-abdominal or visceral obesity is associated with an increased risk of insulin resistance and cardiovascular diseaseThe purpose of this study was to compare the effects of semaglutide 1.0 mg and canagliflozin 300 mg on the body composition of patients with 8 phase 8 IIIBresearchers will have adults with type 2 diabetes (age 18 years), HbA1c 53-91 mmol / mol (7.0-10.5%), daily stable dose of metformin (1500mg or maximum tolerable dose) and eGFR 60ml min -1 (1.73 m) -2 randomly assigned to semaglutide 1.0 mg once a week and canagliflozin placebo once a week, or canagliflozin 300 mg once a day and semaglutide placebo once a dayUse a full body DXA scan to evaluate body compositionThroughout the trial, study participants and researchers remained blind and evaluated the quality of DXA scans by blind methodChanges in the amount of total fat (kg) from the baseline to the 52nd week are the end point for confirming efficacya subset of 178 participants (semaglutide, n s 88; canagliflozin, n s 90) were screened for DXA scans and randomly included in sub-studiesOf these, 114 participants (semaglutide, n s 53; canagliflozin, n s 61) were included in the efficacy confirmation analysisIn 178 participants in the sub-study, a numerical improvement in the body composition of both treatments, including fat quality, lean meat quality, and visceral fat quality, was observed after 52 weeksWith semaglutide and canagliflozin, the total fat mass (baseline 33.2 kg) was reduced by 3.4 kg and 2.6 kg, respectively (estimated treatment difference: -0.79 (95% CI-2.10, 0.51))Although the total lean meat mass (baseline 51.3 kg) with semaglutide and canagliflozin decreased by 2.3 kg and 1.5 kg respectively (estimated treatment difference: -0.78 ,1.61, 0.04), the proportion of lean meat quality (baseline 59.4%) increased by 1.2% and 1.1% - respectively (estimated treatment difference 0.14 -0.89.17)Changes in visceral fat quality and overall changes in body composition (assessed by fat-lean quality ratio) were comparable in both groupsthere was no significant difference in the effects of semaglutide and canagliflozin on body composition in patients with type 2 diabetes who received a stable dose of metforminAlthough improvements in body composition were observed after treatment in both treatment groups, the specific effects of both treatments on body composition are currently speculative at this stage in the absence of a placebo group
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