Diabetogia: The relationship between birth weight and childhood obesity in Japanese adults and beta cell volume.

!---- Low birth weight was associated with a high risk of diabetes, but there were no reports of a relationship between birth weight and human pancreatic tissue.the study was designed to test the relationship between birth weight and beta cell mass.study included 64 Japanese adults with diabetes and no diabetes who had a pancreatic excision who were able to recall their weight history, including birth weight.insulin and glucagon staining of pancreatic tissue, quantitatively divided cell area (BCA) and cell area (ACA).quantify islet size, density, and cell replication, and assess their relationship to birth weight.study analysis showed a slight positive correlation between birth weight and BCA in participants without diabetes (R - 0.34, p s 0.03).the bcA (1.78 percent -0.74 percent vs. 0.99 percent,0.53 percent, p-0.01) in the group with a childhood history of childhood obesity was higher, while the group withnometry was higher.excluded infants with a childhood history of obesity, the coefficient of birth weight associated with BCA increased (R s 0.51, p slt;0.01).there was no correlation between birth weight and BCA in people with diabetes.there is no correlation between birth weight or ACA, regardless of diabetes.results showed a positive correlation between birth weight and beta cell mass in non-diabetic adults, while childhood obesity history may affect beta cell quality..