Diabetogia: Two-way association analysis between severe depression and cardiovascular metabolic disease

Observational studies show a two-way association between severe depression (MDD) and heart and metabolic diseasesjust published in Diabetogia, analyzed the two-way causal effects of MDD and cardiovascular metabolic diseases, including type 2 diabetes, coronary artery disease (CAD) and heart failureTwo-sample two-way Mendel randomization method (two-sample bidirectional Mendelian randomization) was used for treatmentrecent study analyzed data from large-scale genome-wide association studies in Europe, using 96 SNP sites in MDD, 202 SNPs with type 2 diabetes, 44 SNPs for coronary artery disease and 12 SNPs for heart failureThe genome-wide significance level (p 5 x 10-8) is also used as a tool variableThe main analysis was carried out using random-effect inverse variance weighting method (random-effects inverse-al-weighted method)found that the geneticity of MDD was significantly associated with type 2 diabetes and CAD after being corrected by BonferroniMDD risk increased by 26% (1.26, 95% CI 1.10, 1.43; p- 6 x 10-4) and 16% (1.16, 95% CI 1.05, 1.29; p.0047), respectively, for each increase in LogeThere may also be a link between MDD and heart failure (OR 1.11 (95% CI 1.01, 1.21); p s 0.033)In reverse MR analysis, cardiovascular metabolic disease may not have a genetic cause of MDD (p - 0.948; p s 0.328; p s 0.859)researchers believe MDD is a potential risk factor for type 2 diabetes and coronary artery disease, but the causal relationship between MDD and heart failure needs further study Because people with type 2 diabetes are more likely to develop MDD, attention should be paid to the prevention, management, and treatment of MDD during the diagnosis and treatment of people with diabetes The association between MDD and the risk of heart metabolism MDD is associated with cardiovascular, diabetes, heart failure risk