Diabetogia: Vertical changes in glucose metabolism in women with gestational diabetes from late to post-partum

The purpose of this study was to determine insulin sensitivity (Matsuda insulin sensitivity index) in women with gestational diabetes (GDM), from late pregnancy (week 34-37, day 1) to early postpartum (1-5 days, day 2) and late postnatal (6-12 weeks, day 3)The secondary purpose is to link vertical changes in parental lipids, fat factors, cytokines, and weight to changes in ISOGTT, insulin response, and DIthe researchers used the results of 75 g OGTT to calculate ISOGTT, insulin responses, and DI at 3 point in time (T1, T2, and T3)Measure fat factors, cytokines, and lipids before each OGTTThe changes of each point in time are compared by using the linear mixing effect modelThe assessment of changes in OGTT, insulin response, and DIIS was associated with changes in fat factors, cytokines, and lipids at various point in the mother's timestudy showed that a total of 27 women completed all assessmentsCompared to T1, ISOGTT11.20 (95% CI 8.09, 14.31) units (p- 0.001) in 1-5 days after delivery, 5.49 (95% CI 2.38, 8.60) higher than T1 in 6-12 weeks after delivery (p0.001)Compared to T1, the insulin response value decreased by 699.6 (95% CI 957.5, 441.6) units (p 0.001) and 356.3 (95% CI 614.3, 98.3) units (p s 0.004) at T3 Compared to T1, DI increased by 6434.1 (95% CI 2486.2, 10381.0) units (p -0.001) compared to T1, and 426.0 (95% CI 314.6, 8209.3) units (p s 0.03) at T3 From T1 to T2, the average cholesterol, tricerbrillaton, LDL cholesterol and vldl-cholesterol levels decreased on average (p 0.001), while the average increase in c-reactive protein, IL-6 and IL-8 levels (p 0.001) Average leptin levels drop from T1 to T2 (p - 0.001) The mother's average BMI decreased from T1 to T2 (p - 0.001) and from T3 to T3 (p From T1 to T2, there was no significant correlation between changes in ISOGTT, insulin response and DI and changes in maternal cytokines, fat factors, lipids, or weight results showed that for women with GDM, childbirth was associated with insulin sensitivity and improved insulin production in the first few days The improvement in insulin secretion lasted 6-12 weeks, but insulin sensitivity decreased slightly These changes in glucose metabolism were not related to changes in lipids, leptin, inflammatory markers, or weight