Diabetogia: What role does autoimmune do in the onset of diabetes after the age of 40?

Although type 1 and type 2 diabetes differ in pathophysiological factors such as cellular function, insulin resistance and epitope, there may be some correlationAt present, there are relatively few prospective studies on the relationship between autoimmune and the onset of diabetesIn the European Cancer and Nutrition Interaction Synostic Survey (EPIC), we investigated the relationship between 65 kDa subtype GeneralIzed Anxiety Disorder (GAD65) antibodies and genetic risk scores for type 1 and type 2 diabetes and the incidence of diabetes in adultsanalyzed THE GAD65 antibodies in EPIC participants (over 40 years of age with no known diabetes at baseline) through a radiological combination of random groupings (15,802) and sudden diabetes cases (1181)Calculate the genetic risk score for type 1 diabetes and type 2 diabetesThe relationship between GAD65 antibodies and the onset of diabetes was estimated with the prentice weighted Cox regressionresults showed that after the correction of gender, center, physical activity, smoking status and education, baseline GAD65 antibody positive was associated with the development of diabetes, with a median follow-up time of 10.9 years (GAD65 antibody-positive and negative HR was 1.78; 95% CI 1.43, 2.20)After age and gender adjustment, the genetic risk score for type 1 diabetes was associated with positive GA65 antibodies in subcor (OR per SD genetic risk 1.24; 95% CI1.03, 1.50) and event cases (OR1.97; 95% CI1.72, 2.26), but this is not the case for type 2 diabetesCompared to all other individuals, the highest genetic risk score for type 1 diabetes was 3.23 (95% CI2.10, 4.97) in patients with the highest genetic risk score of GAD65 antibody, indicating that 1.8% of the occurrence of diabetes was attributed to a combination of these risk factorsstudies show that the incidence of diabetes in adults is associated with autoimmune causesTherefore, it may be necessary to re-evaluate the subclassification of current diabetes in adulthood