Diabetologia: Are heart metabolic risk factors the driving factor for peripheral nerve function?

The purpose of this study was to examine the relationship between heart metabolic risk factors and (prediabetes) diabetes and peripheral nerve function (sensory exercise).
researchers previously tested 2,401 adults (40-75 years old) for fasting blood sugar, glycoglobin, triglycol, HDL and LDL cholesterol, inflammation, waist circumference, blood pressure, smoking, glucose metabolism (OGTT) and drug use.
used neurotransmission tests to measure the composite muscle action level, sensory nerve movement amplitude and nerve conduction velocity (NCVs) of the fibula, tibia, and fibula nerves.
, the researchers measured the thumb vibration perception threshold (VPT) and used DN4 interviews to assess neuropathic pain.
researchers assessed the cross-sectional association of risk factors with neural function (using linear regression) and neuropathic pain (using logical regression).
the correlation was adjusted for potential mixing factors and risk factors between them.
linear regression is represented by standardized regression coefficients (β) and 95% CI to compare the size of the associations observed between all risk factors and results.
Of all 6 indicators, high blood sugar (an empty stomach blood sugar or glycated hemoglobin) was associated with poor sensory motor neurofunct function, with fibula and tibia NCV, peri-abdominal blood sugar sD (-0.21, s0.13) and peri-abdominal blood sugar s-0.18 SD (-0.23-0.14).
blood sugar is also associated with high VPT and neuropathic pain.
waist circumference, the worse the fibula nerve function and the higher the VPT.
triglycerides, HDL and LDL cholesterol and blood pressure were not associated with worsening nerve function.
, however, the use of antihypertensive drugs (suggesting a history of hypertension exposure) was associated with a difference between perina complex muscle movement potitude amplitude and NCV.
smoking was associated with poorer nerve function, higher VPT and a higher risk of neuropathic pain.
is associated with worsening nerve function and elevated VPT, but only in people with type 2 diabetes.
type 2 diabetes and mild prediabetes (impaired and/or impaired sugar tolerance on an empty stomach) were associated with poor nerve function, higher VPT, and neuropathic pain (trend p.lt;0.01 for all outcomes).
blood sugar, including non-diabetic ranges, is closely associated with early nerve damage.
, increased waist circumference, inflammation, a history of high blood pressure and smoking can also lead to a separate deterioration in nerve function.
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