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    Home > Active Ingredient News > Endocrine System > Diabetologia: Correlation between oxidized lipids of various polyunsaturated fatty acid metabolic derivatives and the risk of type 1 diabetes

    Diabetologia: Correlation between oxidized lipids of various polyunsaturated fatty acid metabolic derivatives and the risk of type 1 diabetes

    • Last Update: 2021-05-08
    • Source: Internet
    • Author: User
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    Oxidized lipids are lipid mediators derived from polyunsaturated fatty acids.


    This study aims to explore whether oxidized lipids are related to the occurrence of type 1 diabetes .


    This study aims to explore whether oxidized lipids are related to the occurrence of type 1 diabetes .


    This is a nested case-control analysis conducted in the Juvenile Diabetes Autoimmune Study (DAISY), a prospective cohort study of children at risk of type 1 diabetes .


    Immunization with type 1 diabetes, children ARA sources 14 kinds of oxidized lipids, oxidized lipids LA 10 kinds of sources, six kinds of oxidized lipids derived from ALA, DHA derived from four kinds of lipid peroxidation and the associated two oxidative EPA Lipid

    Polyunsaturated fatty acids and their corresponding oxidized lipids

    Polyunsaturated fatty acids and their corresponding oxidized lipids

    The results of the analysis showed that 5-HETE , an oxidized lipid associated with ARA, was associated with an increased risk of type 1 diabetes .


    ARA-related oxidized lipids 5-HETE are associated with increased risk of type 1 diabetes ARA-related oxidized lipids 5-HETE are associated with increased risk of type 1 diabetes 5 LA-related oxidized lipids, 2 ALA-related oxidized lipids, and 1 DHA-related All of them are related to the reduced risk of type 1 diabetes.


    The correlation between various oxidized lipids and the risk of type 1 diabetes

    The correlation between various oxidized lipids and the risk of type 1 diabetes

    Analysis of key time points showed that after autoantibody seroconversion, but not before seroconversion, the risk of type 1 diabetes was associated with higher levels of ARA-related oxidized lipids.


    Summary diagram

    Summary diagram

    All in all, the combined protection of higher levels of LA and ALA-related oxidized lipids indicates that the promotion and regression of inflammation are both important in the occurrence of type 1 diabetes .


    The combined protection of higher levels of LA and ALA-related oxidized lipids indicates that the promotion and regression of inflammation are both important in the occurrence of type 1 diabetes.


    Original source:

    Buckner, T.


    org/10.
    1007/s00125-021-05457-9" target="_blank" rel="noopener">The oxylipin profile is associated with development of type 1 diabetes: the Diabetes Autoimmunity Study in the Young (DAISY) in this message
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