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    Home > Active Ingredient News > Endocrine System > Diabetologia: Correlation between oxidized lipids of various polyunsaturated fatty acid metabolic derivatives and the risk of type 1 diabetes

    Diabetologia: Correlation between oxidized lipids of various polyunsaturated fatty acid metabolic derivatives and the risk of type 1 diabetes

    • Last Update: 2021-05-08
    • Source: Internet
    • Author: User
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    Oxidized lipids are lipid mediators derived from polyunsaturated fatty acids.
    Partially oxidized lipids have pro-inflammatory effects (such as oxidized lipids derived from arachidonic acid [ARA]), and partially oxidized lipids have anti-inflammatory effects (such as α-linolenic acid [ALA], docosahexaenoic acid [ DHA] and eicosapentaenoic acid [EPA] oxidized fats), and some oxidized fats have the above two functions at the same time (such as oxidized fats derived from linoleic acid [LA]).

    This study aims to explore whether oxidized lipids are related to the occurrence of type 1 diabetes .

    This study aims to explore whether oxidized lipids are related to the occurrence of type 1 diabetes .
    diabetes

    This is a nested case-control analysis conducted in the Juvenile Diabetes Autoimmune Study (DAISY), a prospective cohort study of children at risk of type 1 diabetes .
    Seventy-two patients with type 1 diabetes and 71 age-matched control individuals at the time of autoantibody seroconversion were recruited.
    Ultra-high performance liquid chromatography-mass spectrometry (ultra-HPLC-MS/MS) was used to detect 14 types of oxidized lipids from ARA, 10 types of oxidized lipids from LA, and ALA sources in the plasma of subjects at multiple time points .
    The levels of 6 oxidized lipids, 4 oxidized lipids from DHA, and 2 oxidized lipids related to EPA
    .
    A linear mixed model was used to obtain the age-adjusted average value of each oxidized lipid before the onset of type 1 diabetes.

    Immunization with type 1 diabetes, children ARA sources 14 kinds of oxidized lipids, oxidized lipids LA 10 kinds of sources, six kinds of oxidized lipids derived from ALA, DHA derived from four kinds of lipid peroxidation and the associated two oxidative EPA Lipid

    Polyunsaturated fatty acids and their corresponding oxidized lipids

    Polyunsaturated fatty acids and their corresponding oxidized lipids

    The results of the analysis showed that 5-HETE , an oxidized lipid associated with ARA, was associated with an increased risk of type 1 diabetes .
    Five types of LA-related oxidized lipids, two types of ALA-related oxidized lipids, and one type of DHA-related raising children are all associated with a reduced risk of type 1 diabetes .
    Elevated LA and ALA-related oxidized lipids (PC1) were associated with a reduced risk of type 1 diabetes (OR 0.
    61; 95% CI 0.
    40-0.
    94).
    An increase in ARA-related oxidized lipids (PC2) is associated with an increased risk of diabetes (OR 1.
    53; 95% CI 1.
    03-2.
    29).

    ARA-related oxidized lipids 5-HETE are associated with increased risk of type 1 diabetes ARA-related oxidized lipids 5-HETE are associated with increased risk of type 1 diabetes 5 LA-related oxidized lipids, 2 ALA-related oxidized lipids, and 1 DHA-related All of them are related to the reduced risk of type 1 diabetes.
    5 LA-related oxidized lipids, 2 ALA-related oxidized lipids, and 1 DHA-related raising children are all related to a reduced risk of type 1 diabetes

    The correlation between various oxidized lipids and the risk of type 1 diabetes

    The correlation between various oxidized lipids and the risk of type 1 diabetes

    Analysis of key time points showed that after autoantibody seroconversion, but not before seroconversion, the risk of type 1 diabetes was associated with higher levels of ARA-related oxidized lipids.

    Summary diagram

    Summary diagram

    All in all, the combined protection of higher levels of LA and ALA-related oxidized lipids indicates that the promotion and regression of inflammation are both important in the occurrence of type 1 diabetes .
    Once the autoimmune process begins, pro-inflammatory ARA-related oxidized lipids may play an important role.

    The combined protection of higher levels of LA and ALA-related oxidized lipids indicates that the promotion and regression of inflammation are both important in the occurrence of type 1 diabetes.

    Original source:

    Original source:

    Buckner, T.
    , Vanderlinden, LA, DeFelice, BC et al.
    org/10.
    1007/s00125-021-05457-9" target="_blank" rel="noopener">The oxylipin profile is associated with development of type 1 diabetes: the Diabetes Autoimmunity Study in the Young (DAISY) .
    Diabetologia (2021).
    https://doi.
    org /10.
    1007/s00125-021-05457-9

    org/10.
    1007/s00125-021-05457-9" target="_blank" rel="noopener">The oxylipin profile is associated with development of type 1 diabetes: the Diabetes Autoimmunity Study in the Young (DAISY)

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