Oxidized lipids are lipid mediators derived from polyunsaturated fatty acids.
Partially oxidized lipids have pro-inflammatory effects (such as oxidized lipids derived from arachidonic acid [ARA]), and partially oxidized lipids have anti-inflammatory effects (such as α-linolenic acid [ALA], docosahexaenoic acid [ DHA] and eicosapentaenoic acid [EPA] oxidized fats), and some oxidized fats have the above two functions at the same time (such as oxidized fats derived from linoleic acid [LA]).
This study aims to explore whether oxidized lipids are related to the occurrence of type 1 diabetes .
This is a nested case-control analysis conducted in the Juvenile Diabetes Autoimmune Study (DAISY), a prospective cohort study of children at risk of type 1 diabetes .
Seventy-two patients with type 1 diabetes and 71 age-matched control individuals at the time of autoantibody seroconversion were recruited.
Ultra-high performance liquid chromatography-mass spectrometry (ultra-HPLC-MS/MS) was used to detect 14 types of oxidized lipids from ARA, 10 types of oxidized lipids from LA, and ALA sources in the plasma of subjects at multiple time points .
The levels of 6 oxidized lipids, 4 oxidized lipids from DHA, and 2 oxidized lipids related to EPA .
A linear mixed model was used to obtain the age-adjusted average value of each oxidized lipid before the onset of type 1 diabetes.
Polyunsaturated fatty acids and their corresponding oxidized lipidsPolyunsaturated fatty acids and their corresponding oxidized lipids
The results of the analysis showed that 5-HETE , an oxidized lipid associated with ARA, was associated with an increased risk of type 1 diabetes .
Five types of LA-related oxidized lipids, two types of ALA-related oxidized lipids, and one type of DHA-related raising children are all associated with a reduced risk of type 1 diabetes .
Elevated LA and ALA-related oxidized lipids (PC1) were associated with a reduced risk of type 1 diabetes (OR 0.
61; 95% CI 0.
An increase in ARA-related oxidized lipids (PC2) is associated with an increased risk of diabetes (OR 1.
53; 95% CI 1.
5 LA-related oxidized lipids, 2 ALA-related oxidized lipids, and 1 DHA-related raising children are all related to a reduced risk of type 1 diabetes
The correlation between various oxidized lipids and the risk of type 1 diabetesThe correlation between various oxidized lipids and the risk of type 1 diabetes
Analysis of key time points showed that after autoantibody seroconversion, but not before seroconversion, the risk of type 1 diabetes was associated with higher levels of ARA-related oxidized lipids.
Summary diagramSummary diagram
All in all, the combined protection of higher levels of LA and ALA-related oxidized lipids indicates that the promotion and regression of inflammation are both important in the occurrence of type 1 diabetes .
Once the autoimmune process begins, pro-inflammatory ARA-related oxidized lipids may play an important role.
Original source:Original source:
, Vanderlinden, LA, DeFelice, BC et al.
1007/s00125-021-05457-9" target="_blank" rel="noopener">The oxylipin profile is associated with development of type 1 diabetes: the Diabetes Autoimmunity Study in the Young (DAISY) .
1007/s00125-021-05457-9" target="_blank" rel="noopener">The oxylipin profile is associated with development of type 1 diabetes: the Diabetes Autoimmunity Study in the Young (DAISY)
in this message