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Several studies have investigated the impact of maternal hyperglycemia on the health of offspring
Adverse effects of the fetal period may increase the risk of future cardiovascular outcomes
A recent Danish cohort study showed that children under the age of 40 and adults have a higher risk of early cardiovascular disease if the mother has diabetes before or during pregnancy
If the mother has diabetes before or during pregnancy, children under the age of 40 and adults have a higher risk of early cardiovascular disease
Research methods:
The selected transgenic Tet29 rat model was generated in a Sprague-Dawley background and carries a DNA structure that produces shRNA that interferes with the expression of the insulin receptor
After the experiment, the rats were decapitated and sacrificed under 1.
The cardiac phenotype was assessed by echocardiography, circulating factors, immunohistochemistry, and cardiac gene expression
Research result:
When fed normally, the offspring of adult diabetic and normoglycemic rats had no significant differences in cardiac function, gene expression and plasma brain natriuretic peptide levels
Figure 1 The experimental mating scheme and follow-up of the transgenic rat model and maternal blood glucose during pregnancy
Figure 1 The experimental mating scheme and follow-up of the transgenic rat model and maternal blood glucose during pregnancy
Figure 2 In-depth analysis of STE on offspring after diet adjustment
Figure 2 In-depth analysis of STE on offspring after diet adjustment
Figure 3 Convergent basic echocardiogram and in-depth analysis of the offspring of an eating disorder
Figure 3 Convergent basic echocardiogram and in-depth analysis of the offspring of an eating disorder
Shows the heart gene expression profile of the offspring caused by HFD
Shows the heart gene expression profile of the offspring caused by HFD
Immunohistochemical study on the heart tissue of the offspring
Immunohistochemical study on the heart tissue of the offspring
.
WGA staining was used to measure the circumference of cardiomyocytes on the cross section of the heart.
Compared with ctrl(A), the cardiomyocytes of DBTC progeny fed with high-fat diet increased significantly
.
COL1 was measured to compare the relationship between the area of fibrosis around the blood vessel and the area of the blood vessel wall
.
Compared with the control group (B), the DBTC progeny did not change
.
Compared with ctrl(C), the number of CD68-positive cells ED1 detected in DBTC progeny increased significantly
.
Male WT offspring of normal blood sugar (Ctrl, NC/Hfd, n=6) and diabetic rats (DBTC, NC/Hfd, n=6/6), scale WGA/COL1/ED1 10/100/20μm, unpaired t Inspection, mean ±SEM, **p≤0.
01, *p≤0.
001
Conclusion: Only after high-fat diet in diabetic pregnant rats can cause cardiac dysfunction, left ventricular hypertrophy and pro-inflammatory changes in the offspring of adult rats
.
Diabetic pregnancy alone is not enough to impair myocardial function and gene expression in adult male offspring
.
This indicates that high-fat diet is of great significance to the occurrence of cardiac dysfunction in the offspring of rats after diabetic pregnancy
.
Diabetic pregnancy is a new heart risk factor.
When there are other risk factors, such as a high-fat diet, this factor is more related to heart changes
.
.
Diabetic pregnancy alone is not enough to impair myocardial function and gene expression in adult male offspring
.
This indicates that high-fat diet is of great significance to the occurrence of cardiac dysfunction in the offspring of rats after diabetic pregnancy
.
Diabetic pregnancy is a new heart risk factor.
When there are other risk factors, such as a high-fat diet, this factor is more related to heart changes
.
Original source:
Schütte T, Kedziora SM, Haase N,et al.
Diabetic pregnancy as a novel risk factor for cardiac dysfunction in the offspring-the heart as a target for fetal programming in rats.
Diabetologia 2021 Sep 18
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