Diabetologia: Early and late histological confirmation of celiac disease in children with new-onset type 1 diabetes

Background: Celiac disease is a common complication of type 1 diabetes in children and adolescents

Background: Celiac disease is a common complication of type 1 diabetes in children and adolescents

OBJECTIVE: The aim of this study was to analyze whether children and adolescents with new-onset type 1 diabetes and a positive screening result could delay the diagnosis of celiac disease

METHODS: This was a multicenter population cohort study

RESULTS: Among 92,278 children and adolescents diagnosed with type 1 diabetes, 26,952 (29.

Figure 1 (a) Proportion of children and adolescents with new-onset type 1 diabetes who received tTGA antibody screening at the onset of type 1 diabetes and (b) histology for celiac disease following a positive screening result since 2001

Figure 1 (a) Proportion of children and adolescents with new-onset type 1 diabetes who received tTGA antibody screening at the onset of type 1 diabetes and (b) histology for celiac disease following a positive screening result since 2001

Table 1 Adjusted outcome variables for participants with early versus delayed histological diagnosis of celiac disease (n = 411) at the last follow-up visit

Figure 2 SDS values ​​of (a) height and (b) body mass index in patients with early versus delayed biopsy-proven celiac disease

Figure 2 SDS values ​​of (a) height and (b) body mass index in patients with early versus delayed biopsy-proven celiac disease

Table 2 assesses acute complications of diabetes in patients with early versus delayed histologically diagnosed celiac disease (n = 411)

Conclusions: Our study suggests that in asymptomatic patients with new-onset type 1 diabetes, the histological diagnosis of celiac disease may be delayed

Conclusions: Our study suggests that in asymptomatic patients with new-onset type 1 diabetes, the histological diagnosis of celiac disease may be delayed

Original source: Kamrath C, Tittel SR, Dunstheimer D, et al.
Early vs late histological confirmation of coeliac disease in children with new-onset type 1 diabetes.
Diabetologia 2022 Apr 30 Early vs late histological confirmation of coeliac disease in children with new- onset type 1 diabetes.


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